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Gellan gum-based hydrogel bilayered scaffolds for osteochondral tissue engineering

It has been shown that hydrogel bilayered scaffolds combining cartilage- and bone-like layers are most advantageous for treating osteochondral defects. In this study, it is proposed the use of low acyl gellan gum (LAGG) for developing bilayered hydrogel scaffolds for osteochondral tissue engineering. The cartilage-like layer of the GG-based bilayered hydrogel scaffolds is composed of LAGG (2 wt%). By adding a 2...

Hydrogels in acellular and cellular strategies for intervertebral disc regenera...

Low back pain is an extremely common illness syndrome that causes patient suffering and disability and requires urgent solutions to improve the quality of life of these patients. Treatment options aimed to regenerate the intervertebral disc (IVD) are still under development. The cellular complexity of IVD, and consequently its fine regulatory system, makes it a challenge to the scientific community. Biomaterial...

Regeneration of the intervertebral disc

Degeneration of intervertebral disc (IVD) seems to be one of the main causes associated to lower back pain (LBP), one of the most common painful conditions that lead to work absenteeism, medical visits, and hospitalization in actual society [1,2]. This complex fibro-cartilaginous structure is composed by two structures, an outer multilayer fiber structure (annulus fibrosus, AF) and a gel-like inner core (nucleu...

Novel bilayered Gellan gum/Gellan gum hydroxyapatite scaffolds for osteochondra...

Osteoarthritis is a major cause of disability during aging. By the age of 60, close to 100% of the population will have histologic changes of degeneration in their knee cartilage (Loeser, 2000). Because of its avascular nature, cartilage has little capacity to self-regenerate. Despite the progress already achieved in osteochondral regeneration, some limitations have to be overcome. The formation of fibrocartila...

Microparticles loaded gellan gum hydrogel matrices : engineering tissues for nu...

The intervertebral disc central core is made by a gel-like tissue structure composed of more than 80% of water, Nucleus Pulposus (NP). Proteoglycans such as versican and especially aggrecan are the main constituents of the NP matrix as well as collagen type II. The purpose of this work is creating novel Gellan gum-based (GG) hydrogel formulations. GG microparticles (MPs) dispersed in a GG matrix are the novelty...

Gellan-gum based bilayered scaffolds for application in osteochondral tissue en...

Publicado em "Journal ofTissue Engineering and Regenerative Medicine", vol. 7, supp. 1 (2013) ; Bilayered scaffold and cellular strategies are currently applied to solve the challenging problem of osteochondral defects. In this study, several formulations of Gellan gum were developed to fabricate different scaf- folds possessing a cartilage-like layer and a bone-like layer. The bone- like layers were obtained ...

Hydrogels in acellular and cellular strategies for intervertebral disc regenera...

Article first published online: 9 nov. 2011 ; Low back pain is an extremely common illness syndrome causing patient’s suffering and disability which demands for urgent solutions in order to improve life quality of the patients. Treatment options aimed to regenerate the intervertebral disc (IVD) are still under development. The huge cellular complexity of IVD, and consequently its fine regulatory system, makes ...

Development of gellan gum-based microparticles/hydrogel matrices for applicatio...

Low back pain is one of the most reported medical conditions associated to intervertebral disc (IVD) degeneration. Nucleus pulposus (NP) is often regarded as the structure where intervertebral disc degeneration begins. Gellan gum-based (GG) hydrogels for acellular and cellular tissue engineering strategies have been developed for finding applications as NP substitutes. The innovative strategy is based on the re...

Novel gellan gum hydrogels for tissue engineering of intervertebral disc