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Gellan gum-based hydrogel bilayered scaffolds for osteochondral tissue engineering

It has been shown that hydrogel bilayered scaffolds combining cartilage- and bone-like layers are most advantageous for treating osteochondral defects. In this study, it is proposed the use of low acyl gellan gum (LAGG) for developing bilayered hydrogel scaffolds for osteochondral tissue engineering. The cartilage-like layer of the GG-based bilayered hydrogel scaffolds is composed of LAGG (2 wt%). By adding a 2...

Escalonamento de plataformas de erosão marinha na praia de Fornelos (Montedor, ...

The present study identifies the staircase development of shore platforms at Montedor - Viana do Castelo, using the data obtained by the method of Communicating Vessels and GPS. It was found that both devices provide identical results and operation time. There were identified four different shore platforms above the actual (0,4/1,8 meters), at 2,8/3,4 - 4,5/5,5 - 6,6/7,4 and 8,5/9,2 meters. A tectono-eustatic o...

Estratigrafia e interpretação paleográfica do Cenozóico continental do norte de...

Evaluation of elderly persons' functionality and care needs

OBJECTIVE: To evaluate the elderly persons' functionality, based on the International Classification of Functionality. METHODS: a cross-sectional, descriptive study; a stratified random sample of 903 elderly persons; a confidence level of 95%; and a margin of error of 2.5%. Questionnaire based on the International Classification of Functionality; data was collected based on structured interviews undertaken by ...

Hydrogels in acellular and cellular strategies for intervertebral disc regenera...

Low back pain is an extremely common illness syndrome that causes patient suffering and disability and requires urgent solutions to improve the quality of life of these patients. Treatment options aimed to regenerate the intervertebral disc (IVD) are still under development. The cellular complexity of IVD, and consequently its fine regulatory system, makes it a challenge to the scientific community. Biomaterial...

Geodiversity assessment of the Xingu drainage basin

Artigo com mapa em anexo ; Geodiversity is a recent concept that refers to the abiotic variety of nature. It is defined as the range of geological (rocks, minerals, fossils), geomorphological (landforms, processes) and soil features, including their assemblages, relationships, properties, interpretation and systems. In this work, a method of quantitative assessment of geodiversity was applied to the Xingu drai...

Geodiversity assessment of Paraná state (Brazil) : an innovative approach

Geodiversity is considered as the natural range of geological, geomorphological, and soil features, including their assemblages, relationships, properties, interpretations, and systems. A method developed for the quantitative assessment of geodiversity was applied to Parana ́ , a Brazilian state with an area of about 200,000 km2. The method is based on the overlay of a grid over different maps at scales ranging...

Regeneration of the intervertebral disc

Degeneration of intervertebral disc (IVD) seems to be one of the main causes associated to lower back pain (LBP), one of the most common painful conditions that lead to work absenteeism, medical visits, and hospitalization in actual society [1,2]. This complex fibro-cartilaginous structure is composed by two structures, an outer multilayer fiber structure (annulus fibrosus, AF) and a gel-like inner core (nucleu...

The impact of GGH -401C>T polymorphism on cisplatin-based chemoradiotherapy res...

AIMS: Cervical cancer is the third most frequent cancer in women worldwide, mostly treated with cisplatin-based chemoradiotherapy. Since it is known that folate metabolism might interfere with cisplatin effectiveness, we intended to study the influence of the Gamma Glutamyl Hydrolase -401C>T polymorphism in treatment response in cervical cancer. METHODS: We retrospectively reviewed the clinical data of 167 pati...

The impact of GGH -401C>T polymorphism on cisplatin-based chemoradiotherapy res...

AIMS: Cervical cancer is the third most frequent cancer in women worldwide, mostly treated with cisplatin-based chemoradiotherapy. Since it is known that folate metabolism might interfere with cisplatin effectiveness, we intended to study the influence of the Gamma Glutamyl Hydrolase -401C>T polymorphism in treatment response in cervical cancer. METHODS: We retrospectively reviewed the clinical data of 167 pati...