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The release of calcium from the endoplasmic reticulum induced by amyloid-beta a...
Ferreiro, Elisabete; Oliveira, Catarina R.; Pereira, Cláudia M.F.In this study, we analyzed whether ER Ca2+ release, induced by amyloid-[beta] (A[beta]) and prion (PrP) peptides activates the mitochondrial-mediated apoptotic pathway. In cortical neurons, addition of the synthetic A[beta]1-40 or PrP106-126 peptides depletes ER Ca2+ content, leading to cytosolic Ca2+ overload. The Ca2+ released through ryanodine (RyR) and inositol 1,4,5-trisphosphate (IP3R) receptors was shown...
An endoplasmic-reticulum-specific apoptotic pathway is involved in prion and am...
Ferreiro, Elisabete; Resende, Rosa; Costa, Rui; Oliveira, Catarina R.; Pereira, Cláudia M.F.Prion (PrP) and amyloid-[beta] (A[beta]) peptides are involved in the neuronal loss that occurs in Prion disorders (PrD) and Alzheimer's disease (AD), respectively, partially due to Ca2+ dysregulation. Besides, the endoplasmic reticulum (ER) stress has an active role in the neurotoxic mechanisms that lead to these pathologies. Here, we analyzed whether the ER-mediated apoptotic pathway is involved in the toxic ...
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