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Dynamic culturing of cartilage tissue : the significance of hydrostatic pressure
Correia, Cristina; Pereira, Ana L.; Duarte, Ana Rita C.; Frias, A. M.; Pedro, A. J.; Oliveira, João T.; Sousa, R. A.; Reis, R. L.Human articular cartilage functions under a wide range of mechanical loads in synovial joints, where hydrostatic pressure (HP) is the prevalent actuating force. We hypothesized that the formation of engineered cartilage can be augmented by applying such physiologic stimuli to chondrogenic cells or stem cells, cultured in hydrogels, using custom-designed HP bioreactors. To test this hypothesis, we investigated t...
Motor-Independent Targeting of CLASPs to Kinetochores by CENP-E Promotes Microt...
Maffin, Stefano; Maia, Ana R. R.; Manning, Amity L.; Maliga, Zoltan; Pereira, Ana L.; Junqueira, Magno; Shevchenko, Andrej; Hyman, AnthonyEfficient chromosome segregation during mitosis relies on the coordinated activity of molecular motors with proteins that regulate kinetochore attachments to dynamic spindle microtubules [1]. CLASPs are conserved kinetochore- and microtubule-associated proteins encoded by two paralogue genes, clasp1 and clasp2, and have been previously implicated in the regulation of kinetochore-microtubule dynamics [2-4]. Howe...
Mammalian CLASP1 and CLASP2 cooperate to ensure mitotic fidelity by regulating ...
Pereira, Ana L.; Pereira, António J.; Maia, Ana R.R.; Drabek, Ksenija; Sayas, C. Laura; Hergert, Polla J.; Lince-Faria, Mariana; Matos, IrinaCLASPs are widely conserved microtubule plus-end–tracking proteins with essential roles in the local regulation of microtubule dynamics. In yeast, Drosophila, and Xenopus, a single CLASP orthologue is present, which is required for mitotic spindle assembly by regulating microtubule dynamics at the kinetochore. In mammals, however, only CLASP1 has been directly implicated in cell division, despite the existence ...
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