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Does Pro12Ala polymorphism enhance the physiological role of PPARy2?
Pereira, A. C.; Oliveira, R.; Castro, A. C.; Fernandes, RúbenObesity and type 2 diabetes mellitus (T2D) are two major public health problems that have motivated the scientific community to investigate the high contribution of genetic factors to these disorders. The peroxisome proliferator activated by gamma 2 (PPARy2) plays an important role in the lipid metabolism. Since PPARy2 is expressed mainly in adipose tissue, a moderate reduction of its activity influences the se...
Behavior of Holstein milking cows exposed to different environmental conditioni...
Vilela, R.A.; Titto, C.G.; Titto, E.A.L.; Pereira, A.M.F.; Pereira, A.C.A.P.M.; Leme, T.M.Objectives: The aim of the study was to evaluate the behavior of dairy cows in summer in relation to the environmental conditioning system (fans with or without misting). Materials and Methods: Twenty Holstein lactating cows were allotted in free-stall pens, divided in two groups: VN ? with fans plus misting; V ? only with fans. The behavior was estimated as time standing and eating, ruminating and idling activ...
Variants of transcription factor 7-like 2 (TCF7L2) gene and incident glucose in...
Franco,L.F.; Crispim,F.; Pereira,A.C.; Moisés,R.S.Common variants of the transcription factor 7-like 2 (TCF7L2) gene have been found to be associated with type 2 diabetes in different ethnic groups. The Japanese-Brazilian population has one of the highest prevalence rates of diabetes. Therefore, the aim of the present study was to assess whether two single-nucleotide polymorphisms (SNPs) of TCF7L2, rs7903146 and rs12255372, could predict the development of glu...
Effect of polymorphisms of the MTHFR and APOE genes on susceptibility to diabet...
Errera,F.I.V.; Silva,M.E.R.; Yeh,E.; Maranduba,C.M.C.; Folco,B.; Takahashi,W.; Pereira,A.C.; Krieger,J.E.; Passos-Bueno,M.R.Diabetes mellitus (DM) is a highly prevalent complex genetic disorder. There has been a worldwide effort in the identification of susceptibility genes for DM and its complications, and the 5-10-methylenetetrahydrofolate reductase (MTHFR) and apolipoprotein-E (APOE) genes have been considered good candidate susceptibility genes to this condition. The objectives of the present study were to determine if the 677T ...
Control of the rat angiotensin I converting enzyme gene by CRE-like sequences
Xavier-Neto,J.; Pereira,A.C.; Oliveira,E.M.; Miyakawa,A.A.; Junqueira,M.L.; Krieger,J.E.We characterized the role of potential cAMP-responsive elements (CRE) in basal and in induced angiotensin converting enzyme (ACE) gene promoter activity in order to shed light on the regulation of somatic ACE expression. We identified stimulators and repressors of basal expression between 122 and 288 bp and between 415 and 1303 bp upstream from the transcription start site, respectively, using a rabbit endothel...
Biological activity evaluation of dibenzilbutirolactones lignans derivatives ag...
Royo,V.A.; Santos,F.F.; Souza,V.A.; Pereira,A.C.; Da Silva,R.; Vinhólis,A.H.C.; Donate,P.M.; Silva,M.L.A.; Albuquerque,S.; Bastos,J.K.This work reports the results of the in vitro assay against extracellular forms of Leishmania (viannia) braziliensis of eleven dibenzylbutyrolactone derivatives, either isolated from plants or obtained by synthesis. From these, only two showed relative biological activity against the parasite, the raceme mixtures of methylpluviatolide: IC50 = 496 mM and (-)-6,6'- dinitrocubebin: IC50 = 510,4 μM. Thus, it c...
High specificity PCR screening for 22q11.2 microdeletion in three different eth...
Pereira,A.C.; Corrêa,R.F.R.; Mota,G.F.; Kim,C.A.; Mesquita,S.F.; Krieger,J.E.Congenital heart defects are the most common of all human birth defects. Numerous studies have shown that a deletion within chromosome 22q11 is associated with DiGeorge syndrome and certain forms of sporadic congenital cardiovascular disease. We have determined the value of a PCR assay using markers D22S941, D22S944 and D22S264 designed for the screening of 22q11.2 deletion through consecutive homozygosity in a...
Effect of race, genetic population structure, and genetic models in two-locus a...
Pereira,A.C.; Mota,G.A.; Benseñor,I.; Lotufo,P.A.; Krieger,J.E.Previous genetic association studies have overlooked the potential for biased results when analyzing different population structures in ethnically diverse populations. The purpose of the present study was to quantify this bias in two-locus association studies conducted on an admixtured urban population. We studied the genetic structure distribution of angiotensin-converting enzyme insertion/deletion (ACE I/D) a...
Síndrome da resposta inflamatória sistêmica/sepse 3/4 revisão e estudo da termi...
Salles,M. J. C.; Sprovieri,S. R. S.; Bedrikow,R.; Pereira,A. C.; Cardenuto,S. L.; Azevedo,P. R. C.; Silva,T. M.; Golin,V.
Colostro de égua no aleitamento artificial.
UNANIAN, M. M.; SILVA, A .E. D. F. da; PEREIRA, A. C.1994
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