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Hepatite Autoimune - casuística de um serviço de Medicina Interna
Vaio, Teresa; Ferreira, Paulo; Santos, Arsénio; Simã, Adélia; Perdigoto, Rui; Santos, Rui; Carvalho, Armando; Porto, ArmandoIntrodução: A hepatite auto-imune (HAI) é uma inflamação hepática de causa desconhecida, caracterizada pela presença de hepatite de interface na biopsia hepática, de hipergamaglobulinemia e de auto-anticorpos característicos. Objectivo: Avaliar as características clínicas, laboratoriais e histológicas, a resposta à terapêutica e o prognóstico da hepatite auto-imune. Métodos: Análise dos processos clínicos dos d...
Sources of glucose production in cirrhosis by 2H2O ingestion and 2H NMR analysi...
Perdigoto, Rui; Furtado, Alexandre L.; Porto, Armando; Rodrigues, Tiago B.; Geraldes, Carlos F. G. C.; Jones, John G.Plasma glucose 2H enrichment was quantified by 2H NMR in patients with cirrhosis (n=6) and healthy subjects (n=5) fasted for 16 h and given 2H2O to ~0.5% body water. The percent contribution of glycogenolysis and gluconeogenesis to glucose production (GP) was estimated from the relative enrichments of hydrogen 5 and hydrogen 2 of plasma glucose. Fasting plasma glucose levels were normal in both groups (87±7 an...
Integration of [U-13C]glucose and 2H2O for quantification of hepatic glucose pr...
Perdigoto, Rui; Rodrigues, Tiago B.; Furtado, Alexandre L.; Porto, Armando; Geraldes, Carlos F. G. C.; Jones, John G.Glucose metabolism in five healthy subjects fasted for 16 h was measured with a combination of [U-13C]glucose and 2H2O tracers. Phenylbutyric acid was also provided to sample hepatic glutamine for the presence of 13C-isotopomers derived from the incorporation of [U-13C]glucose products into the hepatic Krebs cycle. Glucose production (GP) was quantified by 13C NMR analysis of the monoacetone derivative of plasm...
Quantitation of absolute 2H enrichment of plasma glucose by 2H NMR analysis of ...
Jones, John G.; Perdigoto, Rui; Rodrigues, Tiago B.; Geraldes, Carlos F. G. C.A simple 2H NMR method for quantifying absolute 2H-enrichments in all seven aliphatic positions of glucose following its derivatization to monoacetone glucose is presented. The method is based on the addition of a small quantity of 2H-enriched formate to the NMR sample. When the method was applied to [2-2H]monoacetone glucose samples prepared from [2-2H]glucose standards of known enrichments in the range of 0.2...
Síndrome de Sweet. Afecção cutânea benigna ou sistémica grave?
Leitão, Jorge; Reis, Conceição; Malcata, Armando; Carvalho, Armando; Feio, Madalena; Perdigoto, Rui; Costa, Nascimento; Silva, Jorge; Moura, Joséo síndrome de Sweet é uma dermatose aguda febril neutrofílica que, pelas suas manifestações e pela frequência com que envolve outros órgãos e se associa a doenças infecciosas, inflamatórias ou neoplásicas, pode motivar internamentos em enfermarias de Medicina Interna ou de Reumatologia. Os autores analisam retrospectivamente seis casos de síndrome de Sweet internados num serviço de Medicina Interna e Reumatolog...
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