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Polymorphism in gidB gene as a genetic marker for the mycobacterium tuberculosi...
Perdigão, João; Macedo, Rita; Machado, Diana; Silva, Carla; Jordão, Luisa; Couto, Isabel; Viveiros, Miguel; Portugal, IsabelDevelopment of streptomycin-resistance in Mycobacterium tuberculosis is usually associated with mutations in rpsL and rrs genes, although up to 50% of clinical streptomycin-resistant isolates may present no mutation in either of these genes. The situation in Lisbon Health Region is similar, although mutations in rrs gene are only rarely detected. In the present report we investigate the role of gidB gene mutati...
Novel Mutations in pncA, Associated With Catalytic Centre, Might Be Related Wit...
Silva, Carla; Perdigao, João; Jordao, Luísa; Portugal, IsabelTuberculosis (TB) remains a serious health problem worldwide, and the greatest threat to TB control is the emergence of multidrug (MDR) Mycobacterium tuberculosis (Mtb) strains. Pyrazinamide (PZA) is an important first-line anti-TB drug. The emergence of isolates resistant to PZA, associated with MDR resistance, difficult TB treatment options. In order to evaluate mutations that might be responsible for PZA res...
Genomic diversity of drug-resistant mycobacterium tuberculosis isolates in Lisb...
Perdigão, João; Silva, Hugo; Machado, Diana; Macedo, Rita; Maltez, Fernando; Silva, Carla; Jordão, Luisa; Couto, Isabel; Mallard, Kim; Coll, FrancescMultidrug- (MDR) and extensively drug resistant (XDR) tuberculosis (TB) present a challenge to disease control and elimination goals. Lisbon, Portugal, has a high TB incidence rate and, unusual and successful XDR-TB strains that are found in circulation for almost two decades. In the present study, 56 Mycobacterium tuberculosis isolates, mostly recovered in Lisbon, were genotyped by 24-loci Mycobacterial Inters...
Correlation between streptomycin intermediate-level resistance and gidB mutatio...
Perdigao, joão; Macedo, Rita; Machado, Diana; Silva, Carla; Jordao, Luisa; Couto, Isabel; Viveiros, Miguel; Portugal, IsabelDevelopment of streptomycin-resistance in Mycobacterium tuberculosis is usually associated with mutations in rpsL and rrs genes, although up to 50% of clinical streptomycin-resistant isolates may present no mutation in either of these genes. The situation in Lisbon Health Region is similar, although mutations in rrs geneare only rarely detected. In the present report we investigate the role of gidB gene mutatio...
Exploring a link between mycobacteria structure and virulence
Silva, Carla; Perdigao, Joao; Alverca, Elsa; Matos, António Pedro Alves; Carvalho, Patrícia A; Portugal, Isabel; Jordao, LuisaTuberculosis (TB) is a major health problem. The emergence of multidrug resistant (MDR)Mycobacterium tuberculosis (Mtb) isolates confounds treatment strategies. In Portugal, cases of MDR-TB are reported annually with increased incidence noted in Lisbon. The majority of these MDR-TB cases are due to closely-related mycobacteria known collectively as Lisboa family and Q1 cluster. The genetic determinants linked t...
Molecular analysis on resistant TB isolates in Portugal
Silva, Carla; Perdigao, Joao; Jordao, Luisa; Portugal, IsabelAbstrat publicado em: http://www.pasteur.fr/infosci/conf/sb/tuberculosis2012/images/TB2012-Program-Abstract-book-LD.pdf ; Portugal has one of the highest tuberculosis (TB) incidence (20/100 000 inhabitants) in Europe. The emergence of multidrug resistant (MDR) TB and extensive drug-resistant (XDR) TB infection is the biggest threat to TB control. Most strains of MDR-TB circulating in the Lisbon area belong to ...
Dynamics and Development of Extensively Drug-resistant Tuberculosis, Portugal
Perdigao, Joao; Silva, D.; Pereira, V.; Macedo, Rita; Silva, Carla; Machado, Diana; Couto, Isabel; Viveiros, Miguel; Jordao, Luisa; Portugal, IsabelAbstrat publicado em: http://www.pasteur.fr/infosci/conf/sb/tuberculosis2012/images/TB2012-Program-Abstract-book-LD.pdf ; The development of multidrug-resistant (MDR) and extensive drug-resistant (XDR) tuberculosis(TB) combined with subsequent transmission constitutes a serious threat to the effective control of tuberculosis in several countries. Lisbon Health Region, despite great progresses in TB management ...
Variabilidade da radiação solar à superfície em Portugal
Perdigão, João; Salgado, Rui; Dasari, Hari; Costa, Maria João; Mendes, Manuel; Nunes, LuísA radiação solar modela o clima do nosso planeta e quaisquer alterações induz variações de temperatura, humidade, precipitação, etc. A radiação solar é também um factor que condiciona níveis económicos, sociais, ambientais e biológicos. Vários estudos indicam que, entre 1950 e meados da década de 80, se registou uma diminuição na radiação solar global que chega à superfície – fenómeno conhecido por “global dimm...
Tuberculose multirresistente em Lisboa
Perdigão, João Ruben LucasTese de mestrado, Biologia (Biologia Molecular e Genética), 2007, Universidade de Lisboa, Faculdade de Ciências ; Portugal apresenta a quarta maior taxa de incidência de tuberculose da União Europeia, 31 casos por cada 100 000 habitantes em 2005. A Região de Saúde de Lisboa e Vale do Tejo, composta pelos distritos de Lisboa, Santarém e Setúbal, apresenta-se como uma das regiões com maior incidência do país. O ...
Sobre a geração de malhas tridimensionais para fins computacionais a partir de ...
N. Perdigão; João Manuel Ribeiro da Silva Tavares; J. A. C. Martins; E. B. Pires; Renato Manuel Natal JorgeNeste artigo revêem-se algumas técnicas de processamento da informação representada em imagens médicas digitais 2D, para obter malhas volúmicas de órgãos do corpo humano para fins computacionais. Os processos descritos neste trabalho são: segmentação de estruturas representadas em imagens médicas, geração de malhas superficiais e posterior pós-processamento (simplificação e suavização), e ainda a geração de mal...
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