Encontrados 25 documentos, a visualizar página 1 de 3

Ordenado por Data

Evidence for diversifying selection in a set of Mycobacterium tuberculosis gene...

Osório, Nuno S.; Rodrigues, Fernando; Gagneux, Sebastien; Pedrosa, Jorge; Pinto-Carbó, Marta; Castro, António G.; Young, Douglas; Comas, Iñaki

The authors acknowledge Margarida Correia-Neves and Catarina L. Santos for helpful comments and suggestions ; Tuberculosis (TB) is a global health problem estimated to kill 1.4 million people per year. Recent advances in the genomics of the causative agents of TB, bacteria known as the Mycobacterium tuberculosis complex (MTBC), have allowed a better comprehension of its population structure and provided the fo...


Mycobacterium tuberculosis strains are differentially recognized by TLRs with a...

Carmona, J. A.; Cruz, Andrea; Teixeira, Lucia de Fatima Moreira; Sousa, Carole Lara Veiga de; Sousa, Jeremy; Osório, Nuno S.; Saraiva, Ana L.

Tuberculosis associates with a wide spectrum of disease outcomes. The Beijing (Bj) lineage of Mycobacterium tuberculosis (Mtb) is suggested to be more virulent than other Mtb lineages and prone to elicit non-protective immune responses. However, highly heterogeneous immune responses were reported upon infection of innate immune cells with Bj strains or stimulation with their glycolipids. Using both in vitro and...


TLR9 activation dampens the early inflammatory response to paracoccidioides bra...

Menino, João F.; Saraiva, Margarida; Alves, Ana G. Gomes; Silva, Diogo; Sturme, Mark H. J.; Gomes, Jéssica Angélica Rezende; Pedrosa, Jorge

Background: Paracoccidioides brasiliensis causes paracoccidioidomycosis, one of the most prevalent systemic mycosis in Latin America. Thus, understanding the characteristics of the protective immune response to P. brasiliensis is of interest, as it may reveal targets for disease control. The initiation of the immune response relies on the activation of pattern recognition receptors, among which are TLRs. Both T...


Phage therapy is effective against infection by Mycobacterium ulcerans in a mur...

Trigo, Gabriela; Martins, Teresa G.; Fraga, Alexandra G.; Longatto Filho, Adhemar; Castro, António G.; Azeredo, Joana; Pedrosa, Jorge

Author Summary : Buruli Ulcer (BU), caused by Mycobacterium ulcerans, is a necrotizing disease of the skin, subcutaneous tissue and bone. Standard treatment of BU patients consists of a combination of the antibiotics rifampicin and streptomycin for 8 weeks. However, in advanced stages of the disease, surgical resection of the destroyed skin is still required. The use of bacterial viruses (bacteriophages) for th...


P. brasiliensis virulence is affected by SconC, the negative regulator of inorg...

Menino, João F.; Saraiva, Margarida; Gomes, Jéssica Angélica Rezende; Sturme, Mark H. J.; Pedrosa, Jorge; Castro, António G.; Ludovico, Paula

Conidia/mycelium-to-yeast transition of Paracoccidioidesbrasiliensis is a critical step for the establishment of paracoccidioidomycosis, a systemic mycosis endemic in Latin America. Thus, knowledge of the factors that mediate this transition is of major importance for the design of intervention strategies. So far, the only known pre-requisites for the accomplishment of the morphological transition are the tempe...


Innovative anti-microbial strategies against buruli ulcer : bacteriophage therapy

Trigo, Gabriela; Martins, Teresa G.; Oliveira, Hugo; Fraga, Alexandra G.; Castro, António G.; Azeredo, Joana; Pedrosa, Jorge


The rs5743836 polymorphism in TLR9 confers a population-based increased risk of...

Carvalho, Agostinho; Cunha, Cristina; Almeida, A. J.; Osório, Nuno S.; Saraiva, Margarida; Coelho, Maria Teixeira; Pedreiro, Susana; Torrado, Egídio

We are grateful to Paulo Vieira, Cecília Leão, Manuel T. Silva, Nuno Sousa, Jorge Correia- Pinto, Joana Palha, Margarida Correia-Neves, Margarida Lima and Matthew Berry for all their input throughout these studies and critical reading of the manuscript. We are grateful to the patients who joint this study as well as to all members of the Life and Health Sciences Research Institute and School of Health Sciences,...


Experimental phage therapy against Mycobacterium ulcerans in mice model

Branquinho, Gabriela Alexandra Trigo; Martins, Teresa G.; Fraga, Alexandra G.; Azeredo, Joana; Castro, António G.; Pedrosa, Jorge


Corticosteroid-Induced Immunosuppression ultimately does not compromise the eff...

Martins, Teresa G.; Trigo, Gabriela; Fraga, Alexandra G.; Gama, José B.; Longatto Filho, Adhemar; Saraiva, Margarida; Silva, Manuel T.

The authors would like to thank Luis Martins, Deolinda Teixeira and Miguel Carneiro for laboratory assistance. Conceived and designed the experiments: TGM MS MTS AGC JP. Performed the experiments: TGM GT AGF JBG ALF. Analyzed the data: TGM ALF MS MTS AGC JP. Contributed reagents/materials/analysis tools: TGM MS MTS AGC JP. Wrote the paper: TGM AGF ALF MS MTS AGC JP. ; Buruli ulcer (BU) is a necrotizing disease...


Local and regional re-establishment of cellular immunity during curative antibi...

Martins, Teresa G.; Gama, José B.; Fraga, Alexandra G.; Saraiva, Margarida; Silva, Manuel T.; Castro, António G.; Pedrosa, Jorge

BACKGROUND: Buruli ulcer (BU) is a neglected necrotizing disease of the skin, subcutaneous tissue and bone, caused by Mycobacterium ulcerans. BU pathogenesis is associated with mycolactone, a lipidic exotoxin with cytotoxic and immunosuppressive properties. Since 2004, the World Health Organization recommends the treatment of BU with a combination of rifampicin and streptomycin (RS). Histological analysis of hu...


25 Resultados

Texto Pesquisado

Refinar resultados

Autor











Data









Tipo de Documento



Recurso


Assunto















    Financiadores do RCAAP

Fundação para a Ciência e a Tecnologia Universidade do Minho   Governo Português Ministério da Educação e Ciência Programa Operacional da Sociedade do Conhecimento União Europeia