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Development of a new application of the comet assay to assess levels of O6-meth...
Ramos, Alice A.; Pedro, Dalila Fernando Neto; Lima, Cristóvão F.; Collins, Andrew R.; Wilson, Cristina PereiraO6-methylguanine (O6meG) is one of the most premutagenic, precarcinogenic, and precytotoxic DNA lesions formed by alkylating agents. Repair of this DNA damage is achieved by the protein MGMT, which transfers the alkyl groups from the O6 position of guanine to a cysteine residue in its active center. Because O6meG repair by MGMT is a stoichiometric reaction that irreversibly inactivates MGMT, which is subsequent...
Data: 2013
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Origem: RepositóriUM - Universidade do Minho
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