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Ursolic acid induces cell death and modulates autophagy through JNK pathway in ...

Colorectal carcinomas (CRCs) with P53 mutations have been shown to be resistant to chemotherapy with 5-fluorouracil (5-FU), the most widely used chemotherapeutic drug for CRC treatment. Autophagy is emerging as a promising therapeutic target for drug-resistant tumors. In the present study, we tested the effects of ursolic acid (UA), a natural triterpenoid, on cell death mechanisms and its effects in combination...

Ursolic acid, a dietary phytochemical, decreases KRAS signaling and modulates c...

Publicado em "BMC Proceedings 2012, 6(Suppl 3)" ; KRAS mutations are frequent in colorectal cancer (CRC) and have the potential to activate proliferation and inhibit cell death through effects on MAPK/ERK and PI3K/Akt signaling pathways. Because diet is one of the most important determinants of CRC incidence and progression, we studied the effects of the dietary triterpenoid ursolic acid (UA) on proliferation ...

Diet supplemented with UA or EGCG confer protection against DNA damage in colon...

Diet is an important factor in colorectal cancer. High fat diets are considered a risk factor for the development of colon cancer as they increase the content of bile acids in the colon. Bile acids have shown to induce the formation of reactive oxygen and nitrogen species, and these, in turn, induce DNA damage. On the other hand, diets rich in fruits and vegetables have shown preventive effects on colon cancer....

Diet and DNA damage : in vivo effects of dietary compounds on isolated colonocy...

Diet and colon cancer - modulation of signaling pathways and DNA damage prevention

Colorectal cancer (CRC) is a common malignancy and significant cause of death in Western societies. It develops through an accumulation of genetic and epigenetic alterations, transforming normal cells and giving them growth advantage. Many food plants are rich in bioactive compounds and have shown to posses anticancer properties. We proposed to explore the effects of sage (Salvia officinalis (SO)) water extract...

DNA damage prevention and signaling pathway regulation by sage in a colon cance...

Colorectal cancer (CRC) is a common malignancy and significant cause of mortality in Western societies. It develops through an accumulation of genetic and epigenetic alterations, transforming normal colon cells and giving them growth advantage. Many food plants are rich in bioactive compounds and have shown to posses anticancer properties. We proposed to explore the effects of sage (Salvia officinalis (SO)) wat...