Encontrados 2 documentos, a visualizar página 1 de 1
NPY Y1 receptor is not involved in the hemodynamic response to an acute cold pr...
Cavadas, Cláudia; Waeber, Bernard; Pedrazzini, Thierry; Grand, Daniela; Aubert, Jean-François; Buclin, Thierry; Grouzmann, EricThe vasoconstrictor neuropeptide Y (NPY) has been shown to down-regulate tyrosine hydroxylase expression in cultured adrenal chromaffin cells, which probably accounts for the higher plasma resting norepinephrine (NE) and epinephrine (E) concentrations observed in Y1 knock-out mice (Y1-/-) than in wild-type mice (Y1+/+). The aim of this work was to study the hemodynamic response of Y1-/- mice to an acute stimula...
Deletion of the neuropeptide Y (NPY) Y1 receptor gene reveals a regulatory role...
Cavadas, Cláudia; Céfai, Daniel; Rosmaninho-Salgado, Joana; Vieira-Coelho, Maria Augusta; Moura, Eduardo; Busso, Nathalie; Pedrazzini, ThierryThe contribution of neuropeptide Y (NPY), deriving from adrenal medulla, to the adrenosympathetic tone is unknown. We found that in response to NPY, primary cultures of mouse adrenal chromaffin cells secreted catecholamine, and that this effect was abolished in cultures from NPY Y(1) receptor knockout mice (Y(1)-/-). Compared with wild-type mice (Y(1)+/+), the adrenal content and constitutive release of catecho...
| Financiadores do RCAAP | |||||||
|
|
|
|
|
|
||