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Differential Internalization of Amphotericin B - Conjugated Nanoparticles in Hu...
Paulo, CS; Lino, MM; Matos, AA; Ferreira, LSAlthough a variety of nanoparticles (NPs) functionalized with amphotericin B, an antifungal agent widely used in the clinic, have been studied in the last years their cytotoxicity profile remains elusive. Here we show that human endothelial cells take up high amounts of silica nanoparticles (SNPs) conjugated with amphotericin B (AmB) (SNP-AmB) (65.4 12.4 pg of Si per cell) through macropinocytosis while human f...
Antimicrobial susceptibility determined by the E test, Löwenstein-Jensen propor...
Freixo,Maria Inês Moura; Caldas,Paulo CS; Said,Abbadi; Martins,Fátima; Brito,Rossana Coimbra; Fonseca,Leila de Souza; Saad,Maria Helena FéresMycobacterium tuberculosis strains resistant to streptomycin (SM), isoniazid (INH), and/or rifampin (RIF) as determined by the conventional Löwenstein-Jensen proportion method (LJPM) were compared with the E test, a minimum inhibitory concentration susceptibility method. Discrepant isolates were further evaluated by BACTEC and by DNA sequence analyses for mutations in genes most often associated with resistance...
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