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Fratura Proximal do Fémur Bilateral. Incidência e Fatores de Risco de Fratura C...

Constantino, H; Ferrão Patrício, P; Pedrosa, C; Guerra Pinto, F; Ventura Pereira; Diogo, N

Nos doentes com fratura osteoporótica da extremidade proximal do fémur, pouco é conhecido sobre a incidência e fatores de risco de fratura contralateral da extremidade proximal do fémur. O objetivo deste trabalho foi, através de um estudo retrospetivo determinar a incidência e os fatores de risco para fratura bilateral da extremidade proximal do fémur não contemporânea. Foram analisados os processos de 1911 doe...


Sustained remission from depressive-like behavior depends on hippocampal neurog...

Pinheiro, António Mateus; Pinto, Luísa; Bessa, J. M.; Morais, Mónica; Alves, N. D.; Monteiro, S.; Patrício, P.; Almeida, O. F. X.; Sousa, Nuno

We thank M Carneiro and L Martins for technical assistance. AM-P, LP, MM and SM received fellowships from the Portuguese Foundation for Science and Technology (FCT). This work was supported by FCT (PTDC/SAU-NEU/105180/2008) and the ICVS. ; Impairment of hippocampal neurogenesis has been associated with the expression of depressive-like symptoms and some studies have suggested neurogenesis as a critical factor ...


Re-cycling paradigms : cell cycle regulation in adult hippocampal neurogenesis ...

Patrício, P.; Pinheiro, António Mateus; Sousa, Nuno; Pinto, Luísa

Since adult neurogenesis became a widely accepted phenomenon, much effort has been put in trying to understand the mechanisms involved in its regulation. In addition, the pathophysiology of several neuropsychiatric disorders, such as depression, has been associated with imbalances in adult hippocampal neurogenesis. These imbalances may ultimately reflect alterations at the cell cycle level, as a common mechanis...


Re-cycling paradigms : cell cycle regulation in adult hippocampal neurogenesis ...

Patrício, P.; Pinheiro, António Mateus; Sousa, Nuno; Pinto, Luísa

Since adult neurogenesis became a widely accepted phenomenon, much effort has been put in trying to understand the mechanisms involved in its regulation. In addition, the pathophysiology of several neuropsychiatric disorders, such as depression, has been associated with imbalances in adult hippocampal neurogenesis. These imbalances may ultimately reflect alterations at the cell cycle level, as a common mechanis...


Cell genesis and dendritic plasticity : a neuroplastic pas de deux in the onset...

Pinheiro, António Mateus; Patrício, P.; Bessa, J. M.; Sousa, Nuno; Pinto, Luísa

Brain neuroplasticity is increasingly considered to be an important component of both the pathology and treatment of depressive spectrum disorders. Recent studies shed light on the relevance of hippocampal cell genesis and cortico-limbic dendritic plasticity for the development and remission from depressive-like behavior. However, the neurobiological significance of neuroplastic phenomena in this context is sti...


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Fundação para a Ciência e a Tecnologia Universidade do Minho   Governo Português Ministério da Educação e Ciência Programa Operacional da Sociedade do Conhecimento União Europeia