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Functional biopolymer-based matrices for modulation of chronic wound enzyme act...

Francesko, Antonio; da Costa, Diana Soares; Reis, R. L.; Pashkuleva, I.; Tzanov, Tzanko

Collagen, collagen/hyaluronic acid (HA) and collagen/HA/chitosan (CS) sponges loaded with epigallocatechin gallate (EGCG), catechin (CAT) and gallic acid (GA) were developed and evaluated as active chronic wound dressings. Their physico-mechanical properties, biostability, biocompatibility and ability to inhibit in vitro myeloperoxidase (MPO) and collagenase—major enzymes related with the persistent inflammatio...


New biotextiles for tissue engineering : development, characterization and in v...

Almeida, L. R.; Martins, A. R.; Fernandes, E. M.; Oliveira, Mariana B.; Correlo, V. M.; Pashkuleva, I.; Marques, A. P.; Ribeiro, Ana S.

This work proposes biodegradable textile-based structures for tissue engineering applications. We describe the use of two polymers, polybutylene succinate (PBS) proposed as a viable multifilamentand silk fibroin (SF), to produce fibre-based finely tuned porous architectures by weft knitting. PBS is here proposed as a viable extruded multifilament fibre to be processed by a textile-based technology. A comparativ...


Adhesion of adipose-derived mesenchymal stem cells to patterned protein-glycosa...

Costa, Diana Soares da; Márquez-Posadas, M. C.; Araújo, A. R.; Yang, Y.; Becher, J.; Schnabelrauch, M.; Merino, S.; Groth, T.; Reis, R. L.

Publicado em "Journal of Tissue Engineering and Regenerative Medicine", vol. 7, supp. 1 (2013) ; Proteins and glycosaminoglycans (GAGs) are the main constituents of the extracellular matrix (ECM). Until very recently, GAGs were considered as pure structural components while proteins have been associated with crucial cell signalling processes. Nowadays, it is well accepted that these two ECM components act in s...


Nanocarriers based on interpolyelectrolyte complexation of Sulphated polysaccha...

Novoa-Carballal, R.; Reis, R. L.; Pashkuleva, I.

Publicado em "Journal of Tissue Engeneering and Regenerative Medicine", vol. 7, supp. 1 (2013) ; Glycosaminoglycans (GAGs) are integral part of the closest cellular environment: they can be found on the cells surface and in the extracellular matrix, where they interact with different proteins acting as local regulator of their activity. The use of GAGs in the preparation of protein delivery nanosystems is, the...


Sulfation degree of glycosaminoglycans triggers distinct cytoskeleton organisat...

Costa, Diana Soares da; Yang, Y.; Moller, Stephanie; Groth, T.; Reis, R. L.; Pashkuleva, I.

Glycosaminoglycans (GAGs) comprise the closest cellular environment: they are building elements of the ECM and can be also found on cells surface. Their biological activity depends on several parameters among which the negative charge is of prime importance[1]. This charge is generally associated with the presence of sulfate groups (-OSO3H). Sulfation is a dynamic modification: it can occur at various positions...


Sulfonic groups induce formation of filopodia in mesenchymal stem cells

Costa, Diana Soares da; Pires, R. A.; Frias, A. M.; Reis, R. L.; Pashkuleva, I.

Glycosaminoglycans (GAGs) are an integral part of the extracellular matrix and glycocalix, i.e. the closest cellular environment. They are abundant in –OH groups and their bioactivity is also associated with the presence of negatively charged –SO3H functionalities. Therefore, we have investigated and discussed the influence of these functional units on mesenchymal stem cells (MSCs) behaviour using single compon...


Bioactive glass/polymer composite scaffolds mimicking bone tissue

Gentile, Piergiorgio; Mattioli-Belmonte, Monica; Chiono, Valeria; Ferretti, Concetta; Baino, Francesco; Tonda-Turo, Chiara; Vitale-Brovarone, Chiara

The aim of this work was the preparation and characterization of scaffolds with mechanical and functional properties able to regenerate bone. Porous scaffolds made of chitosan/gelatin (POL) blends containing different amounts of a bioactive glass (CEL2), as inorganic material stimulating biomineralization, were fabricated by freeze-drying. Foams with different compositions (CEL2/POL 0/100; 40/60; 70/30 wt %/wt)...


GAGs-thiolated chitosan assemblies for chronic wounds treatment : control of en...

Francesko, Antonio; Costa, Diana Soares da; Lisboa, P.; Reis, R. L.; Pashkuleva, I.; Tzanov, Tzanko

Multilayered polyelectrolyte coatings comprising thiolated chitosan (TC) and glycosaminoglycans (GAGs), chondroitin sulphate and hyaluronic acid, were built using a layer-by-layer approach. The surface activity of these coatings for binding and inhibition of enzymes related to chronic inflammation, such as collagenase and myeloperoxidase, was assessed. The build-up of five bi-layers of TC/GAGs onto gold surface...


Thiolated chitosan/glycosaminoglycans multilayered films : QCM-D study on the f...

Francesko, Antonio; Díaz-Blanco, Carlos; Lisboa, P.; Costa, Diana Soares da; Pashkuleva, I.; Reis, R. L.; Tzanov, Tzanko

Layer-by-layer technique is widely used to produce polyelectrolyte multilayered films for material surface functionalization. The technique simplicity coupled with the biological potential of biopolymers, e.g. polysaccharides, make such assemblies a suitable choice for many biomedical applications. In this study the formation of the films comprising of thiolated chitosan and glycosaminoglycans (GAGs) by alterna...


Controlling cell behavior through the design of polymer surfaces

Alves, N. M.; Pashkuleva, I.; Reis, R. L.; Mano, J. F.


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    Financiadores do RCAAP

Fundação para a Ciência e a Tecnologia Universidade do Minho   Governo Português Ministério da Educação e Ciência Programa Operacional da Sociedade do Conhecimento União Europeia