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Electrochemistry of nanoscale DNA surface films on carbon
Oliveira-Brett, A. M.; Paquim, A. M. Chiorcea; Diculescu, V. C.; Piedade, J. A. P.A DNA electrochemical biosensor is an integrated receptor-transducer device. The most important step in the development and manufacture of a sensitive DNA-biosensor for the detection of DNA-drug interactions is the immobilization procedure of the nucleic acid probe on the transducer surface. Magnetic A/C Mode atomic force microscopy (MAC Mode AFM) images in air were used to characterize two different procedures...
Synthetic oligonucleotides: AFM characterisation and electroanalytical studies
Brett, A. M. Oliveira; Paquim, A.-M. Chiorcea; Diculescu, V.; Oretskaya, T. S.One of the most important steps in designing more sensitive and stable DNA based biosensors is the immobilisation procedure of the nucleic acid probes on the transducer surface, while maintaining their conformational flexibility. MAC Mode AFM images in air demonstrated that the oligonucleotide sequences adsorb spontaneously on the electrode surface, showing the existence of pores in the adsorbed layer that reve...
AFM and electroanalytical studies of synthetic oligonucleotide hybridization
Paquim, A. -M. Chiorcea; Diculescu, V. C.; Oretskaya, T. S.; Brett, A. M. OliveiraThe first and most important step in the development and manufacture of a sensitive DNA-biosensor for hybridization detection is the immobilization procedure of the nucleic acid probe on the transducer surface, maintaining its mobility and conformational flexibility. MAC Mode AFM images were used to demonstrate that oligonucleotide (ODN) molecules adsorb spontaneously at the electrode surface. After adsorption,...
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