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Timing embryo segmentation : dynamics and regulatory mechanisms of the vertebra...

Resende, Tatiana; Andrade, Raquel P.; Palmeirim, I.

All vertebrate species present a segmented body, easily observed in the vertebrate column and its associated components, which provides a high degree of motility to the adult body and efficient protection of the internal organs. The sequential formation of the segmented precursors of the vertebral column during embryonic development, the somites, is governed by an oscillating genetic network, the somitogenesis ...


Monocarboxylate transporters (MCTs) in gliomas : expression and exploitation as...

Gonçalves, Vera M.; Honavar, Mrinalini; Pinheiro, Céline; Martinho, Olga; Pires, Manuel Melo; Pinheiro, Célia; Cordeiro, Michelle; Bebiano, Gil

Background. Gliomas exhibit high glycolytic rates, and monocarboxylate transporters (MCTs) play a major role in the maintenance of the glycolytic metabolism through the proton-linked transmembrane transport of lactate. However, their role in gliomas is poorly studied. Thus, we aimed to characterize the expression of MCT1, MCT4, and their chaperone CD147 and to assess the therapeutic impact of MCT inhibition in...


The impact of alternative science education methodologies on the motivation and...

Azevedo, Maria Manuel; Fonseca, Fernando; Andrade, Raquel P.; Palmeirim, I.

Fully aware of the increasing importance of active and experimental learning, this study has been conducted in Portugal between 2007 and 2008 and was the first of this kind to ever be conducted in this country. Thirty eight students of the school E.B. 2, 3 D. Maria II (middle school) participated in the extra-curricular activity entitled “Scientists for a Day”, previous developed by the Life and Health Science ...


Joint interpretation of AER/FGF and ZPA/SHH over time and space underlies hairy...

Sheeba, Caroline J.; Palmeirim, I.; Andrade, Raquel P.

The authors are grateful to Cheryll Tickle and Lewis Wolpert for helpful comments and critical reading of the manuscript, to Lisa Gonc¸alves and Tatiana Resende for fruitful discussions, Rute Moura and Paulina Piairo for technical assistance and Baolin Wang for the kind gift of Gli3 antibody. ; Embryo development requires precise orchestration of cell proliferation and differentiation in both time and space. A...


The impact of experimental activities on the motivation and acquisition of scie...

Azevedo, Maria Manuel; Fonseca, Fernando; Brito, C.; Andrade, Raquel P.; Palmeirim, I.; Teixeira, Alexandra Sofia Pereira

Forty students (middle school) participated in the science activity entitled “Scientists for a Day”, developed by the Life and Health Science Research Institute/School of Health Science, University of Minho. The activity consisted in a set of laboratory activities. The general objectives of this activity were to stimulate the pleasure of knowledge, encourage critical views, heighten the interest in science, mot...


Sonic hedgehog in temporal control of somite formation

Resende, Tatiana; Ferreira, M??nica; Teillet, Marie-Aim??e; Tavares, Ana Teresa; Andrade, Raquel P.; Palmeirim, I.

Vertebrate embryo somite formation is temporally controlled by the cyclic expression of somitogenesis clock genes in the presomitic mesoderm (PSM). The somitogenesis clock is believed to be an intrinsic property of this tissue, operating independently of embryonic midline structures and the signaling molecules produced therein, namely Sonic hedgehog (Shh). This work revisits the notochord signaling contribution...


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    Financiadores do RCAAP

Fundação para a Ciência e a Tecnologia Universidade do Minho   Governo Português Ministério da Educação e Ciência Programa Operacional da Sociedade do Conhecimento União Europeia