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Estimating gluconeogenesis by NMR isotopomer distribution analysis of [13 C]bic...
Alves, Tiago Cardoso; Nunes, Patrícia Maria; Palmeira, Carlos Marques; Jones, John Griffith; Carvalho, Rui AlbuquerqueThe gluconeogenic contribution to glucose production in livers isolated from rats fasted for 24 h was determined by 13C-NMR isotopomer distribution analysis of secreted glucose enriched from 99% [13C]bicarbonate (n = 4) and 99% [1-13C]lactate (n = 4). Experiments with 3% 2H2O were also performed, allowing the gluconeogenic contribution to be measured by the relative 2H enrichments at positions 5 and 2 of glucos...
Diabetes and mitochondrial oxidative stress: A study using heart mitochondria f...
Santos, Dario Loureiro; Palmeira, Carlos Marques; Seiça, Raquel; Dias, José; Mesquita, José; Moreno, Antonio Joaquim; Santos, Maria SanchaIncreasing evidence shows that the overproduction of reactive oxygen species, induced by diabetic hyperglycemia, contributes to the development of several cardiopathologies. The susceptibility of diabetic hearts to oxidative stress, induced in vitro by ADP-Fe2+ in mitochondria, was studied in 12-month-old Goto-Kakizaki rats, a model of non-insulin dependent diabetes mellitus, and normal (non-diabetic) Wistar ra...
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