Encontrados 38 documentos, a visualizar página 1 de 4
Antioxidant capacity and toxicological evaluation of pterospartum tridentatum f...
Ferreira, Fernanda M.; Dinis, Lia T.; Azedo, Pedro; Galhano, Cristina; Cardoso, Susana M.; Domingues, M.R.M.; Pereira, Olívia R.; Simões, AnabelaPterospartum tridentatum Willk. (prickled broom) is an autochthonous plant, common in Portuguese territory. The yellow flowers are used in traditional medicine, as a potential cure for all body illnesses, mainly for throat irritation treatment or for diabetes, hypertension and hypercholesterolemia therapy.Despite its traditional use, no toxicological assessment has been performed as we know. A high antioxidant ...
Regulation of the mPTP by SIRT3-mediated deacetylation of CypD at lysine 166 su...
Hafner, Angela V.; Dai, Jing; Gomes, Ana P.; Xiao, Chun-Yang; Palmeira, Carlos M.Cardiac failure is a leading cause of age-related death, though its root cause remains unknown. Mounting evidence implicates a decline in mitochondrial function due to increased opening of the mitochondrial permeability transition pore (mPTP). Here we report that the NAD+-dependent deacetylase SIRT3 deacetylates the regulatory component of the mPTP, cyclophilin D (CypD) on lysine 166, adjacent to the binding si...
Biosensor plates detect mitochondrial physiological regulators and mutations in...
Rolo, Anabela P.; Palmeira, Carlos M.; Cortopassi, Gino A.http://www.sciencedirect.com/science/article/B6W9V-4TMBPVF-7/2/3e75ce2b20adb3707a2d6c0aef2493a0
Lecithotrophic behaviour in zoea and megalopa larvae of the ghost shrimp Lepido...
Abrunhosa,Fernando A.; Simith,Darlan J.B.; Palmeira,Carlos A.M.; Arruda,Danielle C.B.Food supply is considered critical for a successful culturing of decapod larvae. However, some species may present yolk reserve sufficient to complete their larval development without external food supply (known as lecithotrophic larval development). In the present study, two experiments were carried out in order to verify whether the callianassid Lepidophthalmus siriboia have lecithotrophic behaviour or, if th...
The importance of feeding in the larval development of the ghost shrimp Callich...
Abrunhosa,Fernando A.; Arruda,Danielle C.B.; Simith,Darlan J.B.; Palmeira,Carlos A.M.The present study investigated whether the callianassid Callichirus major shows a lecithotrophic behaviour during larval development. Two experiments were carried out. In the first experiment, larvae were subjected to an initial period of feeding, while in the second they were subjected to an initial period of starvation. In Experiment 1, 80% of C. major larvae succeeded moulting to juvenile stage in treatment ...
Estimating gluconeogenesis by NMR isotopomer distribution analysis of [13 C]bic...
Alves, Tiago Cardoso; Nunes, Patrícia Maria; Palmeira, Carlos Marques; Jones, John Griffith; Carvalho, Rui AlbuquerqueThe gluconeogenic contribution to glucose production in livers isolated from rats fasted for 24 h was determined by 13C-NMR isotopomer distribution analysis of secreted glucose enriched from 99% [13C]bicarbonate (n = 4) and 99% [1-13C]lactate (n = 4). Experiments with 3% 2H2O were also performed, allowing the gluconeogenic contribution to be measured by the relative 2H enrichments at positions 5 and 2 of glucos...
Differential alterations in mitochondrial function induced by a choline-deficie...
Teodoro, João S.; Rolo, Anabela P.; Duarte, Filipe V.; Simões, Anabela M.; Palmeira, Carlos M.http://www.sciencedirect.com/science/article/B6W8G-4T72WXD-1/2/734055ec11eadc8100fee13e06c683d5
Indirubin-3'-oxime impairs mitochondrial oxidative phosphorylation and prevents...
Varela, Ana T.; Gomes, Ana P.; Simões, Anabela M.; Teodoro, João S.; Duarte, Filipe V.; Rolo, Anabela P.; Palmeira, Carlos M.http://www.sciencedirect.com/science/article/B6WXH-4T7085D-2/2/535e45a8cc0ac06fe24206561a5ee793
Hyperglycemia decreases mitochondrial function: The regulatory role of mitochon...
Palmeira, Carlos M.; Rolo, Anabela P.; Berthiaume, Jessica; Bjork, James A.; Wallace, Kendall B.Increased generation of reactive oxygen species (ROS) is implicated in "glucose toxicity" in diabetes. However, little is known about the action of glucose on the expression of transcription factors in hepatocytes, especially those involved in mitochondrial DNA (mtDNA) replication and transcription. Since mitochondrial functional capacity is dynamically regulated, we hypothesized that stressful conditions of hy...
Avaliação do conteúdo de DNA por citometria de fluxo em linfomas não Hodgkin de...
Palmeira, Carlos; Ribeiro, Neuza; Ribeiro, Elisabete; Godinho, Inês; Sousa, M. Emília; Caetano, Clarisse; Lima, Eduardo; Martins, Gabrielaos linfomas não Hodgkin de células b (lnH-b) constituem um grupo biologicamente heterogéneo de neoplasias hematológicas. para a sua classificação e definição do prognóstico têm sido referidas, como importantes, diversas variáveis, entre elas a avaliação do conteúdo de DnA por citometria de fluxo. no presente trabalho procurou-se realizar uma análise crítica dos resultados publicados em 1993 aquando da reunião d...
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