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Epithelial cells from lung: production, cultivation and characterization: usage...

Tese de mestrado. Biologia (Biologia Molecular e Genética). Universidade de Lisboa, Faculdade de Ciências, 2012 ; Cystic Fibrosis (CF) is the most common lethal genetic disease among Caucasians. It is caused by mutations in the gene encoding the CF transmembrane conductance regulator (CFTR) protein, a cAMP-regulated chloride (Cl-) channel that functions at the apical membrane of epithelial cells. F508del is th...