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Natural polymorphisms of HIV type 2 pol sequences from drug-naive individuals
Parreira, R.; Monteiro, F.; Pádua, E.; Piedade, J.; Venenno, T.; Paixão, M.T.; Esteves, A.Until today, the susceptibility of human immunodeficiency virus type 2 (HIV-2) to protease and nucleosidic reverse-transcriptase inhibitors (PI and NRTI, respectively) has not been clearly documented. In this report we studied HIV-2 proviral sequences (n = 30) from drug-naive patients. Our results revealed that several amino acid positions in the protease and reverse transcriptase coding sequence harbored resid...
Human Immunodeficiency Virus type 1 seroincidence estimate among a group of dru...
Fernandes, S Bio; Centro de Virologia, Instituto Nacional de Saúde Dr. Ricardo Jorge, Lisboa.; Martins, H Cortes; Trigo, H; Leitão, E; Coutinho, REstimating Human Immunodeficiency Virus type 1 (HIV-1) infection remains one of the great challenges of the epidemiologic surveillance of HIV-1 epidemics. WHO has recently approved a laboratory based strategy that enables the identification of recent infections.To identify the number of recent (incident) infections and estimate the seroincidence of HIV-1, using for the first time in Portugal, a new methodology ...
Natural variation of the nef gene in human immunodeficiency virus type 2 infect...
Pádua, E.; Jenkins, A.; Brown, S.; Bootman, J.; Paixão, M.T.; Almond, N.; Berry, N.Human immunodeficiency virus type 2 (HIV-2) infections cause severe immunodeficiency in humans, although HIV-2 is associated frequently with reduced virulence and pathogenicity compared to HIV-1. Genetic determinants that play a role in HIV pathogenesis are relatively poorly understood but nef has been implicated in inducing a more pathogenic phenotype in vivo. However, relatively little is known about the role...
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