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Relation between Metformin Treatment and the Development of Hyperlactacidemia a...

Guelho, Daniela; Serviço de Endocrinologia, Diabetes e Metabolismo. Centro Hospitalar e Universitário de Coimbra. Coimbra. Portugal.

Introduction: In type 2 diabetic patients treated with metformin the development of hyperlactacidemia or even lactic acidosis seems to result from an acute precipitating event. This study aims to assess the prevalence and relative risk of hyperlactacidemia in diabetic patients admitted in the Emergency Room, the predictive factors for high lactate concentration and the influence of hyperlactacidemia in patients...

Data: 2014   |   Origem: Acta Médica Portuguesa

A aplicação da análise de séries temporais (time series analysis) no estudo da ...

Paiva, Isabel; Ramos, Catarina; Cunha, Lúcio

The present study aims to know the hydrological dynamic of karst massif of Sicó (centre of Portugal). Furthermore, this paper demonstrates that time series analyses (correlation and spectral analysis) can contribute highly to understand the hydrodynamic behaviour of karst aquifers and deduce physical characteristics of the system (degree of karstification, storage capacity). The available data consists of 2 spr...


A APLICAÇÃO DA ANÁLISE DE SÉRIES TEMPORAIS (TIME SERIES ANALYSIS) NO ESTUDO DA ...

Paiva, Isabel; Ramos, Catarina; Cunha, Lúcio

The present study aims to know the hydrological dynamic of karst massif of Sicó (centre of Portugal). Furthermore, this paper demonstrates that time series analyses (correlation and spectral analysis) can contribute highly to understand the hydrodynamic behaviour of karst aquifers and deduce physical characteristics of the system (degree of karstification, storage capacity). The available data consists of 2 spr...


NCRF Nº 1 - estrutura e conteúdos das demosntrações financeiras e implicações f...

Paiva, Isabel Maria Rocha

Dissertação apresentada ao Instituto obtenção do grau de Mestre em Auditoria orientador: Dr. Rodrigo Mário de Oliveira Carvalho ; A informação financeira constitui o elemento determinante no processo de tomada de decisão e um factor essencial ao eficaz funcionamento dos mercados. Assim, as crescentes exigências dos seus utilizadores no sentido de minimizar as inconsistências nos processos contabilísticos aliad...


Intervenção clínica e preventiva nos comportamentos alimentares: um diálogo ent...

Tinoco, Rui; Paiva, Isabel

A modificação de comportamentos alimentares, ao nível terapêutico e preventivo, é um desafio clínico, que exige ferramentas de várias áreas da saúde, como a psicologia e a nutrição. Para além do trabalho articulado com essas áreas, nomeadamente através da referenciação às consultas de especialidade, surge a necessidade de uma intervenção clínica e comunitária de primeira linha, especialmente nos Cuidados de Saú...

Data: 2011   |   Origem: Repositório Comum

Recurrent hypercortisolism after removal of an ACTH secretor pituitary adenoma ...

Santos, Jacinta; Paiva, Isabel; Gomes, Leonor; Batista, Carla; Geraldes, Elisabete; Rito, Manuel; Velez, Ana; Oliveira, Fernando; Carvalheiro, Manuela

A 29 years old patient was sent to our Outpatient Clinic of Endocrinology presenting clinic of hypercortisolism. Laboratorial study: High urinary free cortisol (UFC); serum cortisol - 25 microg/dl (8 am) (5-25) and 20 microg/dL (11pm); ACTH - 20 pg/mL (9-52) (8 am) and 14 pg/mL (11 pm); serum cortisol after dexamethasone suppression test: 14,9 mg/dL; CRH test: elevation of ACTH; Pituitary MRI: microadenoma; abd...

Data: 2010   |   Origem: Acta Médica Portuguesa

Uranium glass in museum collections

Matos, António Pires de; Lopes, Filipa M.; Ruivo, Andreia; Muralha, Vânia S. F.; Lima, Augusta; Duarte, Pedro; Paiva, Isabel; Trindade, Romão

Journal of Cultural Heritage, nº 9 (2008), p. 64-68 ; The presence of uraniumglass objects in museum and private collections has raised radiation protection concerns resulting from possible exposure to ionizing radiation emitted by this type of object. Fourteen glass objects with different uranium contents were studied. Dose rates (b þ g radiation)were measured with a beta/gamma probe at several distances from...

Data: 2008   |   Origem: Repositório Institucional da UNL

Diabetes in the elderly: our reality.

Paiva, Isabel; Baptista, Carla; Ribeiro, Cristina; Leitão, Patrícia; Carvalheiro, Manuela

To evaluate the impact of the aging of our population in the growing of diabetes prevalence, among patients treated inward at our department.The clinical files of 242 diabetics older than eighty years, treated between 1999 and 2002 were studied retrospectively. Demographic (sex, age, year of first contact), clinical (causes of admission, co-morbidities, duration of diabetes, previous hypoglycaemic treatment, du...

Data: 2006   |   Origem: Acta Médica Portuguesa

CYP2D6 genetic polymorphisms are associated with susceptibility to pituitary tu...

Gomes, Leonor; Lemos, Manuel C; Paiva, Isabel; Ribeiro, Cristina; Carvalheiro, Manuela; Regateiro, Fernando J

Several polymorphisms of drug-metabolizing enzymes have been implicated in the susceptibility to tumor development. The role of the CYP2D6, GSTM1 and GSTT1 genes has been extensively studied, with alleles conferring different metabolic efficiencies and tumor risk. We studied the relationship between the main polymorphisms of these genes and the susceptibility to develop pituitary tumors, by performing a case-co...

Data: 2005   |   Origem: Acta Médica Portuguesa

Pharmacological therapy of Cushing's disease.

Paiva, Isabel; Serviço de Endocrinologia, Diabetes e Metabolismo, Hospitais da Universidade de Coimbra, Coimbra.; Ribeiro, Cristina

The curative treatment of Cushing's disease is surgery, mainly transphenoidal surgery. The cure probability is high and the risks or complications are few. However, pharmacotherapy is necessary while localisation of the secreting tumour is not achieved, when there is persistence of hypercortisolism after surgery, or while waiting for effectiveness of radiotherapy. We review the existing drugs, their characteris...

Data: 2005   |   Origem: Acta Médica Portuguesa

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    Financiadores do RCAAP

Fundação para a Ciência e a Tecnologia Universidade do Minho   Governo Português Ministério da Educação e Ciência Programa Operacional da Sociedade do Conhecimento União Europeia