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Tolerogenic versus Inflammatory Activity of Peripheral Blood Monocytes and Dend...
Carvalheiro, T; Rodrigues, A; Lopes, A; Velada, I; Ribeiro, A; Martinho, A; Inês, L; Pereira da Silva, JA; Pais, ML; Paiva, AAbnormalities in monocytes and in peripheral blood dendritic cells (DC) subsets have been reported in systemic lupus erythematosus (SLE). We aim to clarify the tolerogenic or inflammatory role of these cells based on ICOSL or IFN-α and chemokine mRNA expression, respectively, after cell purification. The study included 18 SLE patients with active disease (ASLE), 25 with inactive disease (ISLE), and 30 healthy c...
Functional characterization of peripheral blood dendritic cells and monocytes i...
Henriques, A; Inês, L; Carvalheiro, T; Couto, M; Andrade, A; Pedreiro, S; Laranjeiro, P; Morgado, JM; Pais, ML; Pereira da Silva, JA; Paiva, AWith the purpose of contributing to a better knowledge of the APCs functional activity in SLE, we evaluated the distribution and functional ability to produce pro-inflammatory cytokines (TNF-α, IL-1β, IL-6 and IL-12) of peripheral blood (PB) monocytes and DC (tDC), particularly myeloid (mDC) and CD14(-/low)CD16(+) DC subpopulations comparing them with those obtained from healthy individuals. The study was perfo...
Th17 cells in systemic lupus erythematosus share functional features with Th17 ...
Henriques, A; Inês, L; Pais, ML; Pereira da Silva, JA; Paiva, AAThis study was designed to investigate the functional heterogeneity of human Th17 and how their plasticity shapes the nature of immune cell responses to inflammation and autoimmune diseases, such as systemic lupus erythematosus (SLE). We evaluated functional Th17 cell subsets based on the profile of cytokine production in peripheral blood (PB), bone marrow aspirates (BM) and lymph node biopsies (LN) from health...
Expression patterns of HLA-DR+ or HLA-DR- on CD4+/CD25++/CD127low regulatory T ...
Geraldes, L; Morgado, J; Almeida, A; Todo-Bom, A; Santos, P; Chieira, C; Pais, MLBACKGROUND: Allergic rhinoconjunctivitis induced by pollen is a highly prevalent chronic inflammatory disease in Europe. Parietariajudaica is a frequent trigger in the Mediterranean area. The function of regulatory T cells (Treg cells) in allergy has recently been investigated, but further data are necessary to better understand their role and to find new strategies to treat allergic diseases such as allergic r...
Perioperative tumor cell dissemination in patients with primary or metastatic c...
Tralhão, JG; Hoti, E; Serôdio, M; Laranjeiro, P; Paiva, A; Abrantes, AM; Pais, ML; Botelho, MF; Castro e Sousa, FINTRODUCTION: Although there is general correlation between the TNM stage of colorectal cancer (CRC) and its prognosis, there is often significant variability of tumor behaviour and individual patient outcome, which is unaccounted for by pathologic factors alone. Our aim was to estimate perioperative tumor cell dissemination in patients with primary or CRC liver metastases as a possible factor influencing the o...
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