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Genomic diversity of drug-resistant mycobacterium tuberculosis isolates in Lisb...

Perdigão, João; Silva, Hugo; Machado, Diana; Macedo, Rita; Maltez, Fernando; Silva, Carla; Jordão, Luisa; Couto, Isabel; Mallard, Kim; Coll, Francesc

Multidrug- (MDR) and extensively drug resistant (XDR) tuberculosis (TB) present a challenge to disease control and elimination goals. Lisbon, Portugal, has a high TB incidence rate and, unusual and successful XDR-TB strains that are found in circulation for almost two decades. In the present study, 56 Mycobacterium tuberculosis isolates, mostly recovered in Lisbon, were genotyped by 24-loci Mycobacterial Inters...


Transition of Plasmodium Sporozoites into Liver Stage- Like Forms Is Regulated ...

Gomes-Santos, Carina S. S.; Braks, Joanna; Prudêncio, Miguel; Carret, Céline; Gomes, Ana Rita; Pain, Arnab; Feltwell, Theresa; Khan, Shahid

Many eukaryotic developmental and cell fate decisions that are effected post-transcriptionally involve RNA binding proteins as regulators of translation of key mRNAs. In malaria parasites (Plasmodium spp.), the development of round, non-motile and replicating exo-erythrocytic liver stage forms from slender, motile and cell-cycle arrested sporozoites is believed to depend on environmental changes experienced dur...


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