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Sports related oro-facial injuries: which kind of mouthguard will be the most s...

Avaliação do potencial genotóxico do extrato bruto de Pyrostegia venusta (Ker G...

Pyrostegia venusta (Ker Gawl.) Miers, Bignoneaceae, é utilizada no tratamento de vitiligo e de outras doenças, mas seus efeitos genotóxicos não são conhecidos. Neste sentido, o presente estudo teve por objetivo avaliar o efeito genotóxico de extratos de P. venusta em camundongos utilizando os Testes de Micronúcleo (MN) e o de Aberração Cromossômica (AC). O vegetal foi coletado, selecionado, seco, triturado e ex...

Kalirin: a novel genetic risk factor for ischemic stroke

Cerebrovascular and cardiovascular diseases are the leading causes of death and disability worldwide. They are complex disorders resulting from the interplay of genetic and environmental factors, and may share several susceptibility genes. Several recent studies have implicated variants of the Kalirin (KALRN) gene with susceptibility to cardiovascular and metabolic phenotypes, but no studies have yet been perfo...

Mutations of the GLA gene in young patients with stroke: the PORTYSTROKE study-...

BACKGROUND AND PURPOSE: Fabry disease is an X-linked monogenic disorder caused by mutations in the GLA gene. Recent data suggest that stroke in young adults may be associated with Fabry disease. We aimed to ascertain the prevalence of this disorder among young adult patients with stroke in Portugal by GLA genotyping. METHODS: During 1 year, all patients aged 18 to 55 years with first-ever stroke, who were admit...

Selective serotonin-reuptake inhibitor and norepinephrine dopamine reuptake inh...

OBJECTIVE: This study aims to evaluate the citotoxic activity of two commonly used anti-depressants: paroxetine and bupropion. We also evaluated the in vitro natural killer activity (NKA) after incubating the blood samples with the antidepressants. METHODS: Peripheral blood samples from 15 healthy volunteers were collected and the mononuclear cells (PBMCs) were isolated and incubated for 24h with (or without = ...

De uma Convulsão com Rabdomiólise ao Diagnóstico Familiar de Doença de McArdle

RESUMO As miopatias metabólicas são doenças provocadas por defeitos na utilização das reservas energéticas dos tecidos musculares. Apresentam-se por intolerância ao exercício, com fadiga ou mialgias e, por vezes, com mioglobinúria. A Doença de McArdle (doença de armazenamento do glicogénio tipo V) é uma doença deste grupo, com um modo de transmissão autossómico recessivo, causada por mutações no gene PYGM, loca...

Mitochondrial haplogroup H1 is protective for ischemic stroke in Portuguese pat...

BACKGROUND: The genetic contribution to stroke is well established but it has proven difficult to identify the genes and the disease-associated alleles mediating this effect, possibly because only nuclear genes have been intensely investigated so far. Mitochondrial DNA (mtDNA) has been implicated in several disorders having stroke as one of its clinical manifestations. The aim of this case-control study was to ...

Mitochondrial haplogroup H1 is protective for ischemic stroke in Portuguese pat...

The genetic contribution to stroke is well established but it has proven difficult to identify the genes and the disease-associated alleles mediating this effect, possibly because only nuclear genes have been intensely investigated so far. Mitochondrial DNA (mtDNA) has been implicated in several disorders having stroke as one of its clinical manifestations. The aim of this case-control study was to assess the c...

The Portuguese language version of social phobia and Anxiety Inventory: analysi...

OBJECTIVE: Theoretical and empirical analysis of items and internal consistency of the Portuguese-language version of Social Phobia and Anxiety Inventory (SPAI-Portuguese). METHODS: Social phobia experts conducted a 45-item content analysis of the SPAI-Portuguese administered to a sample of 1,014 university students. Item discrimination was evaluated by Student's t test; interitem, mean and item-to-total correl...

Influência de leguminosas no controle de fitonematóides no cultivo orgânico de ...

A demanda por produtos orgânicos é crescente devido às restrições ao uso dos agroquímicos sintéticos. Para verificar o efeito das plantas antagonistas no controle de fitonematóides na cultura da alface americana (Lactuca sativa) e do repolho (Brassica oleracea var. capitata), em cultivo orgânico, instalou-se um experimento na Universidade Federal de Lavras, no período de dezembro de 2001 a agosto de 2002. O del...