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Endothelialization of chitosan porous conduits via immobilization of a recombin...

Amaral, I. F.; Neiva, I.; Silva, F. Ferreira da; Sousa, S. R.; Piloto, A. M.; Lopes, C. D. F.; Barbosa, Mário A.; Kirkpatrick, C. J.; Pêgo, A. P.

The present study aimed to develop a pre-endothelialized chitosan (CH) porous hollowed scaffold for application in spinal cord regenerative therapies. CH conduits with different degrees of acetylation (DA; 4% and 15%) were prepared, characterized (microstructure, porosity and water uptake) and functionalized with a recombinant fragment of human fibronectin (rhFNIII7–10). Immobilized rhFNIII7–10 was characterize...


Protein matrices for improved wound healing : elastase inhibition by a syntheti...

Vasconcelos, Andreia; Pêgo, A. P.; Lamghari, M.; Henriques, L.; Paulo, Artur Cavaco

The unique properties of silk fibroin were combined with keratin to develop new wound-dressing materials. Silk fibroin/keratin (SF/K) films were prepared to reduce high levels of elastase found on chronic wounds. This improved biological function was achieved by the incorporation of a small peptide synthesized based on the reactive-site loop of the Bowman−Birk Inhibitor (BBI) protein. In vitro degradation and r...


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    Financiadores do RCAAP

Fundação para a Ciência e a Tecnologia Universidade do Minho   Governo Português Ministério da Educação e Ciência Programa Operacional da Sociedade do Conhecimento União Europeia