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Endothelialization of chitosan porous conduits via immobilization of a recombin...

Amaral, I. F.; Neiva, I.; Silva, F. Ferreira da; Sousa, S. R.; Piloto, A. M.; Lopes, C. D. F.; Barbosa, Mário A.; Kirkpatrick, C. J.; Pêgo, A. P.

The present study aimed to develop a pre-endothelialized chitosan (CH) porous hollowed scaffold for application in spinal cord regenerative therapies. CH conduits with different degrees of acetylation (DA; 4% and 15%) were prepared, characterized (microstructure, porosity and water uptake) and functionalized with a recombinant fragment of human fibronectin (rhFNIII7–10). Immobilized rhFNIII7–10 was characterize...


Deciduoid Pleural Mesothelioma - a Rare Entity in a Young Woman

Santos, C; Gamboa, F; Fradinho, F; Pêgo, A; Carvalho, L; Bernardo, J

Deciduoid Mesothelioma is a rare variant of epithelioid mesothelioma; it was initially thought that it only occurred in the peritoneum of young women and had nothing to do with asbestos exposure. However, since these early findings it has also been observed in the pleura and the pericardium, with possible association to asbestos. In general the prognosis is poor compared to epithelioid mesothelioma. 45 cases ha...


Protein matrices for improved wound healing : elastase inhibition by a syntheti...

Vasconcelos, Andreia; Pêgo, A. P.; Lamghari, M.; Henriques, L.; Paulo, Artur Cavaco

The unique properties of silk fibroin were combined with keratin to develop new wound-dressing materials. Silk fibroin/keratin (SF/K) films were prepared to reduce high levels of elastase found on chronic wounds. This improved biological function was achieved by the incorporation of a small peptide synthesized based on the reactive-site loop of the Bowman−Birk Inhibitor (BBI) protein. In vitro degradation and r...


Primary chemotherapy with sequential docetaxel followed by docetaxel and epirub...

Frutuoso, C; Henriques, I; Pazos, I; Abraúl, E; Pego, A; Belo, J; Campos, O; Oliveira, CF

Primary chemotherapy is increasingly used in patients with large operable breast cancer. Docetaxel and epirubicin are the most active agents in breast cancer treatment. PURPOSE: To evaluate clinical response rate, breast conserving surgery and pathological response rate in patients with large operable breast cancer treated with docetaxel followed by docetaxel and epirubicin as primary chemotherapy. PATIENTS AND...


Reacção subclínica do pulmão profundo à amioderona

Freitas, M. S.; Pego, A.; Cordeiro, C. Robalo; Morais, M. E.; Lima, M. A.; Sousa, A.; Macedo, M.; Teixeira, A. M.; Nogueira, L. M.; Neite, I.


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    Financiadores do RCAAP

Fundação para a Ciência e a Tecnologia Universidade do Minho   Governo Português Ministério da Educação e Ciência Programa Operacional da Sociedade do Conhecimento União Europeia