Encontrados 3 documentos, a visualizar página 1 de 1
A lactate shuttle system between tumour and stromal cells is associated with po...
Pértega-Gomes, Nelma; Vizcaíno, José R.; Attig, Jan; Jurmeister, Sarah; Lopes, Carlos; Baltazar, FátimaBackground In a malignant tumour, cancer cells are embedded in stromal cells, namely cancer-associated fibroblasts (CAFs). These CAFs are now accepted as important players in cancer dynamics, being involved in tumour growth and progression. Although there are various reports on the interaction between tumour and stromal cells, the clinico-pathological significance of this cross-talk is still largely unknown. In...
Monocarboxylate transporter 2 (MCT2) as putative biomarker in prostate cancer
Pértega-Gomes, Nelma; Vízcaíno, Ramón; Gouveia, Carlos; Jerónimo, Carmen; Henrique, Rui M.; Lopes, Carlos; Baltazar, FátimaINTRODUCTION: Monocarboxylate transporter 2 (MCT2) is a transmembrane protein involved in the transport of monocarboxylates such as pyruvate and lactate. In a previous study we described overexpression of MCT2 in prostate carcinoma raising the hypothesis of using MCT2 as a possible biomarker in prostate cancer. With the present study we aimed to compare the pattern of expression of MCT2 and alpha-methylacyl-CoA...
Monocarboxylate transporter 4 (MCT4) and CD147 overexpression is associated wit...
Pértega-Gomes, Nelma; Vízcaíno, Ramón; Gonçalves, Vera M.; Pinheiro, Céline; Silva, Joana; Pereira, Helena; Monteiro, Pedro; Henrique, Rui M.BACKGROUND. Monocarboxylate transporters (MCTs) are transmembrane proteins involved in the transport of monocarboxylates across the plasma membrane, which appear to play an important role in solid tumours, however the role of MCTs in prostate cancer is largely unknown.The aim of the present work was to evaluate the clinico-pathological value of monocarboxylate transporters (MCTs) expression, namely MCT1, MCT2 a...
| Financiadores do RCAAP | |||||||
|
|
|
|
|
|
||