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Analysis of longitudinal nef sequence variation throughout HIV-2 infection
Remédios, M.; Paixão, E.; Feliciano, H.; Silva-Graça, A.; Pádua, E.Abstract publicado em: International Journal of Infectious Diseases. 2010;14(Supl 1). ; Background: Human Immunodeficiency Virus type 1 (HIV-1) and type 2 (HIV-2) may case a severe immunodeficiency in humans (AIDS). However HIV-2 is more frequently associated with lower levels of transmission and disease progression, compared with HIV-1 infections. The role of nef gene in vivo during the development of AIDS h...
Natural polymorphisms of HIV type 2 pol sequences from drug-naive individuals
Parreira, R.; Monteiro, F.; Pádua, E.; Piedade, J.; Venenno, T.; Paixão, M.T.; Esteves, A.Until today, the susceptibility of human immunodeficiency virus type 2 (HIV-2) to protease and nucleosidic reverse-transcriptase inhibitors (PI and NRTI, respectively) has not been clearly documented. In this report we studied HIV-2 proviral sequences (n = 30) from drug-naive patients. Our results revealed that several amino acid positions in the protease and reverse transcriptase coding sequence harbored resid...
Natural variation of the nef gene in human immunodeficiency virus type 2 infect...
Pádua, E.; Jenkins, A.; Brown, S.; Bootman, J.; Paixão, M.T.; Almond, N.; Berry, N.Human immunodeficiency virus type 2 (HIV-2) infections cause severe immunodeficiency in humans, although HIV-2 is associated frequently with reduced virulence and pathogenicity compared to HIV-1. Genetic determinants that play a role in HIV pathogenesis are relatively poorly understood but nef has been implicated in inducing a more pathogenic phenotype in vivo. However, relatively little is known about the role...
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