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AQUAGENIC URTICARIA

Aquagenic Urticaria is a rare form of physical urticaria precipitated by water contact with the skin, whatever their temperature and nature. The pathophysiology is not completely understood. We report a case of a 6-year-old boy with erythematous maculopapular skin lesions often associated with pallor, especially that appeared on the chest, arms and legs when he contacted with water, regardless its temperature a...

Oxidative Stress and Drugs of Abuse: An Update

Drug addiction is a public health and social burden. Presently, the most abused illicit substance is cannabis, followed by amphetamines, cocaine and opioids, with different prevalence in different countries. Several evidences support a role for oxidative stress in the toxicity induced by many drugs of abuse in different organs, such as the brain, heart, liver or kidneys. This leads to oxidation of important cel...

Dismorfia Facial e Atraso de Crescimento Intra-Uterino na Acidúria Metilmalónic...

Os autores descrevem o caso clínico de uma criança portadora de acidúria metilmalónica associada a homocistinúria diagnosticada aos nove anos de idade, a qual apresenta dismorfia facial e antecedentes de atraso de crescimento intra-uterino (ACIU). Apesar do diagnóstico e terapêutica tardios, a evolução clínica tem sido favorável.

Herpes Zoster em Lactente — Após Exposição Intrauterina a Varicela

Os autores apresentam o caso de um lactente de sete meses de idade observado por febre e lesões pápulo-vesiculares no membrosuperior e omoplata esquerdos, no trajecto de um dermátomo. Antecedentes de varicela materna às 18-20 semanas de gestação. Apóso diagnóstico clínico de Herpes-Zoster, foi medicado com Acyclovir tópico, tendo-se verificado uma regressão completa das lesõesem 3 semanas. O diagnóstico foi con...

Encefalopatia Aguda Associada à Doença da Arranhadela do Gato

A Doença da Arranhadela do Gato é uma causa frequente de linfadenopatia regional, muitas vezes não diagnosticada, dada a sua evolução habitualmente benigna. As complicações são raras, mas estão descritas, nomeadamente o atingimento do Sistema Nervoso Central.A Encefalopatia Aguda pode ser a primeira manifestação da doença, sendo um dos diagnósticos diferenciais a considerar na criança com convulsões ou coma de ...

Mitochondrial complex I dysfunction induced by cocaine and cocaine plus morphin...

Mitochondrial function and energy metabolism are affected in brains of human cocaine abusers. Cocaine is known to induce mitochondrial dysfunction in cardiac and hepatic tissues, but its effects on brain bioenergetics are less documented. Furthermore, the combination of cocaine and opioids (speedball) was also shown to induce mitochondrial dysfunction. In this work, we compared the effects of cocaine and/or mor...

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WORKSHOP ON SOME PROSPECTIVE ASPECTS IN MATHEMATICS AND STATISTICS

Constantino Lagoa: In this talk, we discuss some preliminary results on a general approach to chance constrained algebraic problems. In this type of problems, one aims at maximizing the probability of a set defined by polynomial inequalities. This class of problems is quite general and includes many problems in control systems where the system of interest is subject to stochastic disturbances and/or random unce...

Dimethylaminopyridine derivatives of lupane triterpenoids cause mitochondrial d...

Triterpenoids are a large class of naturally occurring compounds, and some potentially interesting as anticancer agents have been found to target mitochondria. The objective of the present work was to investigate the mechanisms of mitochondrial toxicity induced by novel dimethylaminopyridine (DMAP) derivatives of pentacyclic triterpenes, which were previously shown to inhibit the growth of melanoma cells in vit...

Biochemistry of adipose tissue: an endocrine organ

Adipose tissue is no longer considered to be an inert tissue that stores fat. This tissue is capable of expanding to accommodate increased lipids through hypertrophy of existing adipocytes and by initiating differentiation of pre-adipocytes. Adipose tissue metabolism exerts an impact on whole-body metabolism. As an endocrine organ, adipose tissue is responsible for the synthesis and secretion of several hormone...