Herein, we describe a 44-year-old female diagnosed with histologically proven coexistence of primary Sjögren's syndrome and sarcoidosis with pulmonary and muscular involvement. The differential diagnosis may be difficult, but this is not an exceptional case, which highlights the need to critically revise the consideration of sarcoidosis as an exclusion for primary Sjögren's syndrome, as established in current c...
Nitric oxide (NO) is a molecular messenger involved in several events of synaptic plasticity in the central nervous system. Ca2+ influx through the N-methyl-D-aspartate receptor (NMDAR) triggers the synthesis of NO by activating the enzyme neuronal nitric oxide synthase (nNOS) in postsynaptic densities. Therefore, NMDAR and nNOS are part of the intricate scenario of postsynaptic densities. In the present study,...
Peripheral glial cells consist of satellite, enteric glial, and Schwann cells. In dorsal root ganglia, besides pseudo-unipolar neurons, myelinated and nonmyelinated fibers, macrophages, and fibroblasts, satellite cells also constitute the resident components. Information on satellite cells is not abundant; however, they appear to provide mechanical and metabolic support for neurons by forming an envelope surrou...
Most adult tissues retain a reservoir of self-renewing, multipotent stem cells that can generate differentiated tissue components. Until recently, the brain was thought to be an exception to this rule and for many years the pervasive dogma of neurobiology relegated neurogenesis to the embryonic and earlier postnatal stages of development. The discovery of constant neuronal replacement in the adult brain has cha...
Biol Regul Homeost Agents. 2004 Jul-Dec;18(3-4):392-8. Immunophenotypic approach to the identification and characterization of clonal plasma cells from patients with monoclonal gammopathies. Pérez-Andrés M, Santiago M, Almeida J, Mateo G, Porwit-MacDonald A, Bjorklund E, Valet G, Kraan J, Gratama JW, D'Hautcourt JL, Merle-Beral H, Lima M, Montalban MA, San Miguel JF, Orfao I; European Working Group on Clinical...
Cell migration occurs extensively during mammalian brain development and persists in a few regions in the adult brain. Defective migratory behavior of neurons is thought to be the underlying cause of several congenital disorders. Knowledge of the dynamics and molecular mechanisms of neuronal movement could expand our understanding of the normal development of the nervous system as well as help decipher the path...
A qualquer momento, existem cerca de 2000 tempestades com relâmpagos nos cêus em torno do mundo. Estima-se que as tempestades combinadas produzem aproximadamente 100 descargas de raios por segundo, cada uma com temperatura em torno de 30.0000ºC - mais quente que a superfície do Sol. Esse trabalho apresenta aos leitores alguns fenômenos elêtricos na atmosfera e estratosfera. Tais eventos fazem parte de um sugeri...
Human localized cutaneous leishmaniasis (LCL), induced by Leishmania braziliensis, ranges from a clinically mild, self-healing disease with localized cutaneous lesions to severe forms which can present secondary metastatic lesions. The T cell-mediated immune response is extremely important to define the outcome of the disease; however, the underlying mechanisms involved are not fully understood. A flow cytometr...
Traveling convection vortices (TCV) are studied using a theoretical ideal MHD model for the equilibrium and perturbed plasma. In this first approach, we do not consider the viscosity and the flow of the plasma column in the equilibrium. The linearized equations are solved using normal mode analysis. The solutions show an m = 1 kink instability which is in good agreement with the experimental data. It is calcula...
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