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Thymulin inhibits monocrotaline-induced pulmonary hypertension modulating IL-6 ...
Henriques-Coelho, T; Oliveira, SM; Moura, RS; Roncon-Albuquerque R, Jr.; Neves, AL; Santos, M; Nogueira-Silva, C; La Fuente Carvalho, FThe pathogenesis of pulmonary hypertension (PH) includes an inflammatory response. Thymulin, a zinc-dependent thymic hormone, has important immunobiological effects by inhibiting various proinflammatory cytokines and chemokines. We investigated morphological and hemodynamic effects of thymulin administration in a rat model of monocrotaline (MCT)-induced PH, as well as the pattern of proinflammatory cytokine gen...
Ghrelin reverses molecular, structural and hemodynamic alterations of the right...
Henriques-Coelho, T; Roncon-Albuquerque R, Jr.; Lourenço, AP; Baptista, MJ; Oliveira, SM; Brandão-Nogueira, A; Correia-Pinto, J; Leite-Moreira, AFGhrelin is an endogenous peptide that has a dual effect by activating specific receptors and by stimulating release of growth hormone. There is increasing evidence that ghrelin has a potent vasodilator effect. Recently, we demonstrated that exogenous administration of ghrelin modulates its endogenous levels and attenuates the majority of alterations induced by monocrotaline (MCT). In the present study, we evalu...
Human immunodeficiency virus type 1 (HIV-1) genotyping in Rio de Janeiro, Brazi...
Couto-Fernandez,JC; Silva-de-Jesus,C; Veloso,VG; Rachid,M; Gracie,RSG; Chequer-Fernandez,SL; Oliveira,SM; Arakaki-Sanchez,D; Chequer,PJN; Morgado,MGIn order to assess the human immunodeficiency virus type 1 (HIV-1) drug resistance mutation profiles and evaluate the distribution of the genetic subtypes in the state of Rio de Janeiro, Brazil, blood samples from 547 HIV-1 infected patients failing antiretroviral (ARV) therapy, were collected during the years 2002 and 2003 to perform the viral resistance genotyping at the Renageno Laboratory from Rio de Janeir...
Endogenous production of ghrelin and beneficial effects of its exogenous admini...
Henriques-Coelho, T; Correia-Pinto, J; Roncon-Albuquerque R, Jr.; Baptista, MJ; Lourenço, AP; Oliveira, SM; Brandão-Nogueira, A; Teles, A; Fortunato, JMWe investigated the endogenous production of ghrelin as well as cardiac and pulmonary vascular effects of its administration in a rat model of monocrotaline (MCT)-induced pulmonary hypertension (PH). Adult Wistar rats randomly received a subcutaneous injection of MCT (60 mg/kg) or an equal volume of vehicle. One week later, animals were randomly assigned to receive a subcutaneous injection of ghrelin (100 mug/k...
Distinct load dependence of relaxation rate and diastolic function in Oryctolag...
Correia-Pinto, J; Henriques-Coelho, T; Oliveira, SM; Leite-Moreira, AFThis study investigated potential differences on load dependence of relaxation rate and diastolic function between Oryctolagus cuniculus and Ratus norvegicus, which have constitutive differences in the mechanisms involved in myocardial inactivation. Load dependence of relaxation rate and diastolic function were evaluated with the response of left ventricular time constant tau and diastolic pressure-dimension re...
Evaluation of biventricular function in the rat: a new experimental model
Correia-Pinto, J; Henriques-Coelho, T; Oliveira, SM; Moreira, AFThe use of small animals in cardiovascular research has increased over recent years. This might be a limitation when evaluation of biventricular function is required. Although evaluation of left ventricular (LV) pressure and volume is already possible in small animals, concomitant evaluation of right ventricle function has been limited to large animals. The study describes a new model to assess pressures and di...
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