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Bridging systems and synthetic biology for the development of improved microbia...

Stability, dynamics of convergence and tuning of observer-based kinetics estima...

This work discusses issues concerning stability, tuning and dynamics of convergence of observer-based kinetics estimators. The analysis focuses on both continuous and discrete time formulations of the estimation algorithms. Concerning the former, it is shown that, with proper tuning, stability can be guaranteed, while simultaneously imposing a desired quasi-time invariant second order time response for the conv...

A study on the convergence of observer-based kinetics estimators in stirred tan...

This paper is devoted to the tuning problem of an observer-based algorithm for the on-line estimation of reaction rates in stirred tank bioreactors. The relation between the dynamics of convergence and the tuning procedure is explored. The method proposed imposes a variable second-order dynamics on the convergence of the estimator. This approach is shown to compare favourably with a pole placement based techniq...

Model-based estimation of reaction rates in stirred tank bioreactors

In this paper an adaptive model-based algorithm is proposed for the on-line estimation of reaction rates in stirred tank bioreactors. The main design condition imposes that the observation errors reflecting the mismatch between the estimated parameters and the 'true' values follow second-order dynamics of convergence. The gain matrices are shown to be functions of the state and of user-defined damping coefficie...

A study on the convergence of observer-based kinetics estimators in stirred tan...

This paper is devoted to the tuning problem of the "observer-based kinetics estimator" in stirred tank bioreactors. This algorithm estimates the reaction kinetics from the on-line knowledge of the state variables (either from measurement or by means of state observer), when the yield coefficients are known. The relation between the dynamics of convergence and the tuning procedure is explored. The method propose...

Computer-aided teaching of process engineering : VI - studies on bioprocess ide...

In this paper we present a simple computer-based laboratory set-up for experiments concerning real-time system identification. The set-up is constituted by a 'Process Simulator' computer and a 'Control' computer, communicating via serial RS-232 protocol. The former can simulate multivariable non-linear systems in real-time, in this specific experiment the fed-batch fermentation of baker's yeast. The latter perf...