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Chryseobocterium indologenes adhesion and biofilm formation onto biomaterials

Antimicrobial efficacy of naturals compounds in combination with rifampicin aga...

Antifungal activity of phenolic compounds identified in flowers from the North ...

To evaluate the antifungal effect of gallic acid, catechin, luteolin and quercetin, phenolic compounds identified from flowers of North Eastern Portugal, against Candida planktonic and biofilm cells. Materials & methods: The MICs were determined in Candida planktonic cells and the effect of phenolic compounds on Candida biofilms was assessed through quantification of CFUs. Results: MIC values demonstrated that ...

Base de dados internacional de variantes genéticas do gene MTM1: contributos pa...

The impact of microcarrier culture optimization on the glycosylation profile of...

Microcarriers are widely used for the large-scale culture of attachment-dependent cells with increased cell densities and, ultimately, higher product yield. In these processes, the specific culture conditions can affect the quality of the product, which is closely related to its glycosylation pattern. Furthermore, the lack of studies in the area reinforces the need to better understand the effects of microcarri...

Silver colloidal nanoparticles : effect on matrix composition and structure of ...

Aim : The aim of this study was to assess the effect of different silver nanoparticles (SN) concentrations on the matrix composition and structure of Candida albicans and Candida glabrata biofilms. Methods and Results : Candida biofilms were developed in 6-well microtiter plates during 48 h. After, these biofilms were exposed to 13·5 or 54 μg SN ml−1 for 24 h. Then, extracellular matrices were extracted from bi...

Corrosion behaviour of titanium in the presence of Streptococcus mutans

Objective The main aim of this in vitro study was to evaluate the influence of Streptococcus mutans on the corrosion of titanium. Methods S. mutans biofilms were formed on commercially pure titanium (CP-Ti) square samples (10 mm × 10 mm × 1 mm) using a culture medium enriched with sucrose. Open circuit potential (OCP) and electrochemical impedance spectroscopy (EIS) measurements were used to evaluate the cor...

Characterization of phenolic compounds in wild medicinal flowers from Portugal ...

In the present work, the phenolic compounds of Castanea sativa, Filipendula ulmaria and Rosa micrantha flowers from Northeastern Portugal were characterized by HPLC–DAD–ESI/MS. Furthermore, it was performed a screening of their antifungal potential against Candida species (Candida albicans, Candida glabrata, Candida parapsilosis and Candida tropicalis). C. sativa sample gave the highest amount of phenolic comp...

Advances and drawbacks of the adaptation to serum-free culture of CHO-K1 cells ...

Currently, mammalian cell technology has become the focus of biopharmaceutical production, with strict regulatory scrutiny of the techniques employed. Major concerns about the presence of animal-derived components in the culture media led to the development of serum-free (SF) culture processes. However, cell adaptation to SF conditions is still a major challenge and limiting step of process development. Thus, t...

N-acetylcysteine and vancomycin alone and in combination against staphylococci ...

Introduction: The ability of staphylococci to produce biofilm is an important virulence mechanism that allows bacteria both to adhere and to live on artificial surfaces and to resist to the host immune factors and antibiotics. Staphylococcal infections have become increasingly difficult to treat due their antibiotic resistance. Therefore, there is a continuous need for new and effective treatment alternatives a...