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Vantagens Na Utilização do Carvedilol Em Relação Ao Propranolol Na Protecção da...
Oliveira, PJ; Rolo, AP; Sardão, VA; Monteiro, P; Gonçalves, L; Providência, LA; Palmeira, CM; Moreno, AJBACKGROUND: Carvedilol is a neurohormonal antagonist of multiple action which is used in clinical practice for the treatment of congestive heart failure, mild to moderate hypertension and myocardial infarction. Previous results from our group have demonstrated that one of the main targets for the protective effect of carvedilol is the cardiac mitochondrial network. In-this work, we compare the effect of carvedi...
Histological changes and impairment of liver mitochondrial bioenergetics after ...
Palmeira, CM; Ferreira, FM; Rolo, AP; Oliveira, PJ; Santos, MS; Moreno, AJ; Cipriano, MA; Martins, MI; Seiça, RThis study was designed to evaluate the effects of long-term treatment with alpha-naphthyl-isothiocyanate (ANIT) on liver histology and at the mitochondrial bioenergetic level. Since, ANIT has been used as a cholestatic agent and it has been pointed out that an impairment of mitochondrial function is a cause of hepatocyte dysfunction leading to cholestatic liver injury, serum markers of liver injury were measur...
Mitocôndria: que papel na isquémia, reperfusão e morte cerebral?
Monteiro, P; Oliveira, PJ; Gonçalves, LRecent advances in the knowledge of the biochemical basis of myocardial ischemia have enabled a better understanding of the complex sequence of events occurring in ischemic cardiomyopathy, whatever its manifestations. This has clearly highlighted the important role played by cardiac mitochondria in these events. At first only associated with energy production, mitochondria have been clearly shown to have other ...
Carvedilol: Relação Entre A Actividade Antioxidante e Inibição da Transição de ...
Oliveira, PJ; Esteves, T; Rolo, AP; Monteiro, P; Gonçalves, L; Palmeira, CM; Moreno, AJOBJECTIVES: The mitochondrial permeability transition (MPT) is an event related to severe oxidative stress (for example, during myocardial ischemia and reperfusion) and excessive mitochondrial calcium accumulation, also being implicated in cell death. In this study, we compared the effect of carvedilol on the cardiac MPT induced by calcium and phosphate (Ca/Pi) and calcium/carboxyatractyloside (Ca/Catr). Oxidat...
Impacto do Carvedilol Sobre O Dano Mitocondrial Induzido Por Hipoxantina/xantin...
Oliveira, PJ; Rolo, AP; Monteiro, P; Gonçalves, L; Palmeira, CM; Moreno, AJOBJECTIVES: The cardioprotective effects of carvedilol (CV) may be explained in part by interactions with heart mitochondria. The objective of this work was to study the protection afforded by CV against oxidative stress induced in isolated heart mitochondria by hypoxanthine and xanthine oxidase (HX/XO), a well-known source of reactive oxygen species (ROS) in the cardiovascular system. METHODS: Mitochondria wer...
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