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Selective pressure acting on influenza virus neuraminidase protein and relation...
Correia, V.; Santos, L.A.; Giria, M.; Rebelo-de-Andrade, H.Neuraminidase (NA) protein of influenza viruses has the particularity of being under antibody and antiviral drug selective pressure, as it is one of the main surface antigens and the target of neuraminidase inhibitors(NAIs). The aim of this study is to investigate the selective pressure(SP) acting on the NA of seasonal and pandemic influenza viruses. It comprises two objectives: (a)to evaluate the contribution ...
Evaluation and Characterization of Influenza Antiviral Drug Resistance in Portu...
Correia, V.; Santos, L.A.; Giria, M.; Rebelo-de-Andrade, H.In 2007 started to be carried out for the first time in Portugal a study focused on influenza antiviral drug resistance. Three main objectives were established:(1)to determine the antiviral profile of influenza viruses to oseltamivir, zanamivir and amantadine;(2)to determine and monitor the baseline level of susceptibility along winter seasons and for each influenza sub(type);(3)to analyse and characterize the ...
Genomic Signatures and Antiviral Drug Susceptibility Profile of A(H1N1)pdm09
Tiago Gíria, M; Rebelo Andrade, H; Santos, LA; Correia, V; Pedro, S; Almeida Santos, MBackground: Genetic changes in influenza surface and internal genes can alter viral fitness and virulence. Mutation trend analysis and antiviral drug susceptibility profiling of A(H1N1)pdm09 viruses is essential for risk assessment of emergent strains and disease management. Objective: To profile genomic signatures and antiviral drug resistance of A(H1N1)pdm09 viruses and to discuss the potential role of mutate...
Outbreak of acute respiratory infection among infants in Lisbon, Portugal, caus...
Rebelo-de-Andrade, H; Pereira, C; Gíria, M; Prudêncio, E; Brito, MJ; Calé, E; Taveira, NHuman adenoviruses (AdVs) typically cause mild illnesses in otherwise healthy hosts. We investigated a pediatric outbreak of acute respiratory infection with fatal outcomes that occurred in Lisbon, Portugal, in 2004. Biological specimens were collected from 83 children attending two nurseries, a kinesiotherapy clinic, and the household of a nanny. Adenovirus infection was confirmed in 48 children by PCR and vir...
Outbreak of acute respiratory infection among infants in Lisbon, Portugal, caus...
Rebelo-de-Andrade, Helena; Pereia, C.; Giria, M.; Prudêncio, E.; Brito, M.J.; Calé, E.; Taveira, N.Human adenoviruses (AdVs) typically cause mild illnesses in otherwise healthy hosts. We investigated a pediatric outbreak of acute respiratory infection with fatal outcomes that occurred in Lisbon, Portugal, in 2004.Biological specimens were collected from 83 children attending two nurseries, a kinesiotherapy clinic, and the household of a nanny. Adenovirus infection was confirmed in 48 children by PCR and viru...
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