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[15]aneN4S: synthesis, thermodynamic studies and potential applications in chel...
Torres, N.; Gonçalves, S.; Fernandes, A. S.; Machado, J. F.; de Brito, M. J.; Oliveira, N. G.; Castro, M.; Costa, J.; Cabral, M. F.The purpose of this work was to synthesize and characterize the thiatetraaza macrocycle 1-thia-4,7,10,13-tetraazacyclopentadecane ([15]aneN4S). Its acid-base behaviour was studied by potentiometry at 25 °C and ionic strength 0.10 M in KNO3. The protonation sequence of this ligand was investigated by 1H-NMR titration that also allowed the determination of protonation constants in D2O. Binding studies of [15]aneN...
Differential effects of methoxyamine on doxorubicin cytotoxicity and genotoxici...
Guerreiro, P. S.; Fernandes, A. S.; Costa, J. G.; Castro, M.; Miranda, J. P.; Oliveira, N. G.Pharmacological inhibition of DNA repair is a promising approach to increase the effectiveness of anticancer drugs. The chemotherapeutic drug doxorubicin (Dox) may act, in part, by causing oxidative DNA damage. The base excision repair (BER) pathway effects the repair of many DNA lesions induced by reactive oxygen species (ROS). Methoxyamine (MX) is an indirect inhibitor of apurinic/apyrimidinic endonuclease 1 ...
Synthesis and Biological Activity of 6-Selenocaffeine: Potential Modulator of C...
Martins, I. L.; Miranda, J. P.; Oliveira, N. G.; Fernandes, A. S.; Gonçalves, S.; Antunes, A. M.We report the development of a new microwave-based synthetic methodology mediated by Woollins’ reagent that allowed an efficient conversion of caffeine into 6-selenocaffeine. A preliminary evaluation on the modulation of antioxidant activity upon selenation of caffeine, using the DPPH assay, indicated a mild antioxidant activity for 6-selenocaffeine, contrasting with caffeine, that exhibited no antioxidant acti...
Development of pyridine-containing macrocyclic copper(II) complexes: potential ...
Fernandes, A. S.; Costa, J.; Gaspar, J.; Rueff, J.; Cabral, M. F.; Cipriano, M.; Castro, M.; Oliveira, N. G.The unique redox and catalytic chemistry of Cu has justified the development of novel Cu complexes for different therapeutic uses including cancer therapy. In this work, four pyridine-containing aza-macrocyclic copper(II) complexes were prepared (CuL1-CuL4) varying in ring size and/or substituents and their superoxide scavenging activity evaluated. CuL3, the most active superoxide scavenger, was further studied...
Cytotoxic effects of cadmium in mammary epithelial cells: Protective role of th...
Gonçalves, S; Fernandes, A. S.; Oliveira, N. G.; Marques, J.; Costa, J.; Cabral, M. F.; Miranda, J.; Cipriano, M.; Guerreiro, P. S.; Castro, M.Human exposure to cadmium (Cd) occurs via different routes, including diet. The increasing amount of data linking Cd with different cellular effects in the mammary gland justifies additional toxicological assessments using human mammary epithelial cells. This work aimed therefore to assess the cytotoxic effects of Cd in MCF10A cells and to characterize the cytoprotective role of the macrocycle [15]pyN5 in the f...
Gestão de serviços dos ecossistemas em bacias hidrográficas
Guiomar, Nuno; Oliveira, N.G.; Fernandes, J.P.; Teiga, P.; Moreira, M.B.Os serviços de ecossistemas referem-se a uma dimensão normalmente menosprezada das actividades agrícolas e florestais. Com efeito, estas actividades, para além dos produtos transaccionáveis, produzem, ou contribuem para a produção de serviços não transaccionáveis que importa reconhecer, avaliar e, progressivamente, remunerar. Esta remuneração é da maior importância no actual contexto de desvalorização dos rendi...
Custos de implantação e manutenção e receitas brutas obtidas com o cultivo orgâ...
RICCI, M. dos S. F.; OLIVEIRA, N. G. de.O objetivo do trabalho foi avaliar os custos de implantação e de manutenção de duas áreas cultivadas com café arábica, uma conduzida a pleno sol e outra arborizada com banana (Musa sp. var.Prata Comum) e eritrina (Erythrina vema) , bem como avaliar a receita bruta obtida nos dois sistemas de cultivo. Ao todo, nove mil mudas pertencentes a seis cultivares de café (Coffea arabica L.) foram plantadas nos dois sist...
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