Encontrados 5 documentos, a visualizar página 1 de 1
Cryopreservation of cell laden natural origin hydrogels for cartilage regenerat...
Popa, Elena G.; Rodrigues, Márcia T.; Coutinho, Daniela F.; Oliveira, Mariana B.; Mano, J. F.; Reis, R. L.; Gomes, Manuela E.The time span needed for obtaining a functional cartilage substitute using tissue engineering strategies, together with the need for specific patient oriented constructs has stimulated the growing interest for developing “off-the shelf” products. One way to deliver such products is based on long-term storage processes, such as cryopreservation, that will provide the clinical substitute available as needed and c...
New biotextiles for tissue engineering : development, characterization and in v...
Almeida, L. R.; Martins, A. R.; Fernandes, E. M.; Oliveira, Mariana B.; Correlo, V. M.; Pashkuleva, I.; Marques, A. P.; Ribeiro, Ana S.This work proposes biodegradable textile-based structures for tissue engineering applications. We describe the use of two polymers, polybutylene succinate (PBS) proposed as a viable multifilamentand silk fibroin (SF), to produce fibre-based finely tuned porous architectures by weft knitting. PBS is here proposed as a viable extruded multifilament fibre to be processed by a textile-based technology. A comparativ...
Superhydrophobic platforms for the combinatorial analysis of biomaterials-cells...
Oliveira, Mariana B.; Salgado, Christiane L.; Mano, J. F.High-throughput studies of cells mechanotransduction are usually performed using 2D biomaterials. However, cells-extracellular matrix interactions in the body occur in 3D environment. By using cells entrapped in hydrogels, it is not easy to isolate the mechanical effect from the chemical cues of biomaterials. We used a cytocompatible and non-expensive platform based in the patterning of wettable spots in superh...
Development of an injectable system based on elastin-like recombinamer particle...
Oliveira, Mariana B.; Song, Wenlong; Martín, Laura; Oliveira, Sara M.; Caridade, S. G.; Alonso, Matilde; Rodríguez-Cabello, José Carlos; Mano, J. F.An elastin-like recombinamer (ELR) containing the RGD cell adhesion domain was used to fabricate microparticles by an innovative and affordable process based on the use of superhydrophobic surfaces. Two microparticles types with different crosslinking extents were prepared. The biological response was tested using an osteoblast-like cell line (SaOs-2) performing proliferation and alkaline phosphatase (ALP) quan...
Polymer-based microparticles in tissue engineering and regenerative medicine
Oliveira, Mariana B.; Mano, J. F.Different types of biomaterials, processed into different shapes, have been proposed as temporary support for cells in tissue engineering (TE) strategies. The manufacturing methods used in the production of particles in drug delivery strategies have been adapted for the development of microparticles in the fields of TE and regenerative medicine (RM). Microparticles have been applied as building blocks and matri...
| Financiadores do RCAAP | |||||||
|
|
|
|
|
|
||