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Synthesis and biochemical studies of 17-substituted androst-3-enes and 3,4-epox...
Cepa, Margarida M. D. S.; Silva, Elisiário J. Tavares da; Correia-da-Silva, Georgina; Roleira, Fernanda M. F.; Teixeira, Natércia A. A.http://www.sciencedirect.com/science/article/B6TC9-4T0WJXG-2/2/58305e64e3c068f352293a693f168db2
Data: 2008
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Origem: Estudo Geral - Universidade de Coimbra
Structure−Activity Relationships of New A,D-Ring Modified Steroids as Aromatase...
Cepa, Margarida M. D. S.; Silva, Elisiário J. Tavares da; Correia-da-Silva, Georgina; Roleira, Fernanda M. F.; Teixeira, Natércia A. A.Inhibition of aromatase is an efficient approach for the prevention and treatment of breast cancer. New A,D-ring modified steroid analogues of formestane and testolactone were designed and synthesized and their biochemical activity was investigated in vitro in an attempt to find new aromatase inhibitors and to gain insight into their structure−activity relationships (SAR). All compounds tested were less active ...
Data: 2005
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Origem: Estudo Geral - Universidade de Coimbra
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