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Measurement of red blood cells deformation index in a hyperbolic microchannel
Faustino, V.; Pinho, Diana; Yaginuma, Tomoko; Calhelha, Ricardo C.; Man-Kim, Gyeong; Arana, Sergio; Lima, R.; Ferreira, Isabel C.F.R.; Oliveira, M.S.N.A hyperbolic microchannel was used for the purpose of observing the deformation index of the erythrocytes after contact with human tumour cell line (HCT-15 - colon carcinoma). Three cases were compared and the results showed that the deformation index decreases when erythrocytes are in contact with HCT-15.
Human red blood cell behavior under homogeneous extensional flow in a hyperboli...
Yaginuma, Tomoko; Oliveira, M. S. N.; Lima, R.; Ishikawa, T.; Yamaguchi, T.It is well known that certain pathological conditions result in a decrease of red blood cells (RBCs) deformability and subsequently can significantly alter the blood flow in microcirculation, which may block capillaries and cause ischemia in the tissues. Microfluidic systems able to obtain reliable quantitative measurements of RBC deformability hold the key to understand and diagnose RBC related diseases. In th...
Flow of red blood cells through a microfluidic extensional device: an image ana...
Yaginuma, Tomoko; Pereira, Ana I.; Rodrigues, P.J.; Lima, R.; Oliveira, M.S.N.; Ishikawa, Takuji; Yamaguchi, TakamiThe present study aims to assess the deformability of red blood cells (RBCs) under extensionally dominated microfluidic flows using an image based technique. For this purpose, a microchannel having a hyper-bolic shaped-contraction was used and the images were captured by a standard high-speed microscopy system. The images acquired display RBCs with various light intensity levels and image analysis was used to q...
Flow of red blood cells through a microfluidic extensional device : an image an...
Yaginuma, T.; Pereira, Ana I.; Rodrigues, P. J.; Lima, R.; Oliveira, M.S. N.; Ishikawa, T.; Yamaguchi, T.The present study aims to assess the deformability of red blood cells (RBCs) under extensionally dominated microfluidic flows using an image based technique. For this purpose, a microchannel having a hyperbolic shaped-contraction was used and the images were captured by a standard high-speed microscopy system. The images acquired display RBCs with various light intensity levels and image analysis was used to qu...
Modeling and simulation of micro direct methanol Fuel Cells
Falcão, D. S.; Oliveira, V. B.; Oliveira, M. S. N.; Rangel, C. M.Fuel cells have unique technological attributes: efficiency, absence of moving parts and low emissions. The Direct Methanol Fuel Cell (DMFC) has attracted much attention due to its potential applications as a power source for transportation and portable electronic devices. With the advance of micromachining technologies, miniaturization of power sources became one of the trends of evolution of research in this ...
Axisymmetric PDMS (polydimethysiloxane) microchannels for in vitro haemodynami...
Lima, R.; Oliveira, M.S.N.; Ishikawa, Takuji; Kaji, H.; Tanaka, S.; Nishizawa, Matsuhiko; Yamaguchi, TakamiThe current microdevices used for biomedical research are often manufactured using microelectromechanical systems (MEMS) technology. Although it is possible to fabricate precise and reproducible rectangular microchannels using soft lithography techniques, this kind of geometry may not reflect the actual physiology of the microcirculation. Here, we present a simple method to fabricate circular PDMS microchannels...
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