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Abnormal protein phosphorylation in Alzheimer's disease

AD is a neurodegenerative disorder neuropathologically characterized by the presence of senile plaques, neurofibrillary tangles and synaptic loss. The Aβ peptide, the major constituent of senile plaques, is a key player in AD pathology since increased Aβ production and aggregation was associated with neurotoxicity, activation of inflammatory response, and apoptotic cascades. These processes are associated with ...