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Steroselective synthesis of imidazolidin-4-ones from α-amino amides of the anti...
Ferraz, Ricardo; Gomes, José R. B.; Passo, Joana; Oliveira, Eliandre; Moreira, Rui; Gomes, PaulaImidazolidin-4-ones are commonly employed as skeletal modifications in bioactive oligopeptides, either as proline surrogates or for protection of the N-terminal amino acid against aminopeptidase-catalysed hydrolysis . We have been working on the synthesis of imidazolidin-4-ones of the antimalarial primaquine , through acylation of primaquine with an α-amino acid and subsequent reaction of the resulting α-aminoa...
Importance of the solvation degree of peptide-resin beads for amine groups dete...
Cilli,Eduardo M.; Jubilut,Guita N.; Ribeiro,Suely C. F.; Oliveira,Eliandre; Nakaie,Clovis R.The classic and important picric acid method used in polymers biochemical and chemical fields of polymers for amine group quantification was chosen in this work as a model for evaluating the influence of the resin bead solvation during an analytical procedure. It was observed that this method, proposed almost three decades ago, failed to quantify amine groups of peptidyl-resin containing aggregating and polar s...
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