Encontrados 40 documentos, a visualizar página 1 de 4
FASL polymorphism is associated with response to bacillus Calmette-Guérin immun...
Lima, Luís; Ferreira, José Alexandre; Tavares, Ana; Oliveira, Daniela; Morais, António; Videira, Paula; Medeiros, Rui; Santos, LúcioObjective Deregulation of FAS/FASL system may lead to immune escape and influence bacillus Calmette-Guérin (BCG) immunotherapy outcome, which is currently the gold standard adjuvant treatment for high-risk non–muscle invasive bladder tumors. Among other events, functional promoter polymorphisms of FAS and FASL genes may alter their transcriptional activity. Therefore, we aim to evaluate the role of FAS and FASL...
Development of stimuli-responsive smart hydrogels using molecular imprinting an...
Oliveira, Tânia; Reitor, Patrícia; Oliveira, Daniela; Kadhirvel, Porkodi; Dias, Rolando; Costa, MárioDifferent classes of stimuli-responsive smart hydrogels (SRSH) were synthesized in order to assess the usefulness of molecular imprinting and generation of interpenetrating polymer networks to obtain advanced materials with tailored properties/performance. Reversible Addition-Fragmentation Chain-Transfer (RAFT) polymerisation was exploited as an additional tool to increase the control on the formation process o...
Development of tailored hydrogels using RAFT polymerization in continuous flow ...
Machado, Carla; Oliveira, Tânia; Reitor, Patrícia; Oliveira, Daniela; Freitas, Filipa; Kadhirvel, Porkodi; Dias, Rolando; Costa, MárioThis research is devoted to the development of tools aiding the production of smart hydrogels with tailored molecular architecture and properties. Molecular imprinting, RAFT polymerization and operation in continuous flow microreactor are individually considered and also simultaneously combined in order to try the synthesis of materials with improved performance.
Role of Metformin as co-adjuvant in anticancer therapy targeting Osteosarcoma C...
Oliveira, Daniela Isabel Paiva deBackground: Osteosarcoma (OS) is the most common malignant primary bone tumor that appears in childhood and adolescence. It was recently demonstrated that OS possesses a small population with stem-like features, CSCs, which are responsible for the heterogeneity and regenerative ability of tumor cells and are considered responsible for the resistance to conventional therapies, namely chemotherapy and radiotherap...
Identidade e comunicação organizacional - contributos para a construção de uma ...
Oliveira, Daniela Isabel Martins de; Barros, Teresa Antas de; Rasquilha, LuísO Ensino Superior Português atravessa, atualmente, umas das fases mais complexas da sua história. A diminuição do número de candidatos e a quebra significativa do financiamento a par de uma expressiva concorrência, resultante do elevado número de instituições existentes, tornam necessária uma alteração na postura destas instituições. O Marketing tem vindo a assumir um papel cada vez mais presente nas organizaçõ...
Macrophages as biomarkers in BCG treatment response in bladder cancer
Oliveira, DanielaBladder cancer is a common urologic cancer and the majority has origin in the urothelium. Patients with intermediate and high risk of recurrence/progression bladder cancer are treated with intravesical instillation with Bacillus Calmette-Guérin, however, approximately 30% of patients do not respond to treatment. At the moment, there are no accepted biomarkers do predict treatment outcome and an early identifica...
The predominance of M2-polarized macrophages in the stroma of low-hypoxic bladd...
Lima, Luís; Oliveira, Daniela; Tavares, Ana; Amaro, Teresina; Cruz, Ricardo; Ferreira, José Alexandre; Santos, LúcioOBJECTIVE: Bacillus Calmette-Guérin (BCG) immunotherapy is the gold standard treatment for superficial bladder tumors with intermediate/high risk of recurrence or progression. However, approximately 30% of patients fail to respond to the treatment. Effective BCG therapy needs precise activation of the type 1 helper cells immune pathway. Tumor-associated macrophages (TAMs) often assume an immunoregulatory M2 phe...
Caracterização de tráfego de rede : Cloud Storage na Universidade do Minho
Oliveira, Daniela Catarina Ferreira deDissertação de mestrado integrado em Engenharia de Comunicações ; Monitoring of Internet services reveals that there is a growing trend in the use of Cloud Services. Considering the strong growth on the access to these services in a relatively short period of time, it is estimated that shortly they will be responsible for a significant amount of Internet flows. In this context, this project aims to identify an...
As potencialidades da revista National Geographic no Ensino da História e Geogr...
Oliveira, Daniela Primo Ferreira deEstudos realizados no âmbito da Educação indicam que a inserção de artigos de jornal e revistas didáticas no ensino contribui para o enriquecimento das práticas letivas, para a formação dos alunos enquanto cidadãos cientificamente literados e para a promo- ção de uma aprendizagem ao longo da vida. Nas orientações curriculares, para a disci- plina de História e de Geografia do 3.º Ciclo do Ensino Básico e do Ens...
Metabolic alterations in pregnant women: gestational diabetes
Oliveira, Daniela; Pereira, Joana; Fernandes, RúbenGestational diabetes mellitus (GDM) and controversy are old friends. The impact of GDM on maternal and fetal health has been increasingly recognized. Nevertheless, universal consensus on the diagnostic methods and thresholds has long been lacking. Published guidelines from major societies differ significantly from one another, with recommendations ranging from aggressive screening to no routine screening at all...
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