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Cell degeneration induced by amyloid-ß peptides

Abstract Extracellular accumulation of amyloid-ß (Aß) peptide and death of neurons in brain regions involved in learning and memory, particularly the cortex and the hippocampus, are central features of Alzheimer’s disease (AD). Neuronal Ca2+ overload and apoptosis are known to occur in AD. Aß might play a role in disrupting Ca2+ homeostasis, and this AD-associated amyloidogenic peptide has been reported to ind...