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Pain management in neonatal intensive care unit: translating research evidence ...

A socio-demographic study of aging in the Portuguese Population - The EPEPP study

The increase in life expectancy (LE) observed in Western societies, has resulted in a steep rise of older population. This stresses the importance of the research on aging, to better adequate health and social care organization and improve the quality of life (QoL). The aim of the EPEPP-1 (abbreviated from the Portuguese name: Estudo do Perfil de Envelhecimento da Populac¸a˜o Portuguesa) study was to characteri...

Neurotoxic effect of oligomeric and fibrillar species of A<beta>1-42 peptide. I...

http://www.sciencedirect.com/science/article/B6T0F-4SSY90W-1/1/0b10903f573d4beaec42f0dc791857e3

Insulin affects synaptosomal GABA and glutamate transport under oxidative stres...

In this study, we investigated the in vitro effect of exogenously administered insulin on the susceptibility to oxidative stress and on the accumulation of the amino acid neurotransmitters [gamma]-aminobutyric acid (GABA) and glutamate in a synaptosomal fraction isolated from male Wistar rat brain cortex. Insulin (1 [mu]M) did not affect synaptosomal lipid peroxidation induced by the oxidant pair ascorbate/Fe2+...

Oxidative glutamate toxicity involves mitochondrial dysfunction and perturbatio...

Glutamate toxicity on PC12 cells is mediated by oxidative stress as a consequence of the inhibition of a cystine uptake system with depletion of GSH. In this study we report that glutamate decreases PC12 cell viability, inhibiting the reduction of 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT). This decrease was prevented by the antioxidants vitamin E, idebenone and -deprenyl, which were als...