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Oxidative Stress and Drugs of Abuse: An Update
Cunha-Oliveira, Teresa; Rego, A. Cristina; Oliveira, Catarina R.Drug addiction is a public health and social burden. Presently, the most abused illicit substance is cannabis, followed by amphetamines, cocaine and opioids, with different prevalence in different countries. Several evidences support a role for oxidative stress in the toxicity induced by many drugs of abuse in different organs, such as the brain, heart, liver or kidneys. This leads to oxidation of important cel...
Mitochondrial complex I dysfunction induced by cocaine and cocaine plus morphin...
Cunha-Oliveira, Teresa; Silva, Lisbeth; Silva, Ana Maria; Moreno, António J.; Oliveira, Catarina R.; Santos, Maria S.Mitochondrial function and energy metabolism are affected in brains of human cocaine abusers. Cocaine is known to induce mitochondrial dysfunction in cardiac and hepatic tissues, but its effects on brain bioenergetics are less documented. Furthermore, the combination of cocaine and opioids (speedball) was also shown to induce mitochondrial dysfunction. In this work, we compared the effects of cocaine and/or mor...
Activation of the endoplasmic reticulum stress response by the amyloid-beta 1–4...
Fonseca, Ana Catarina R. G.; Ferreiro, Elisabete; Oliveira, Catarina R.; Cardoso, Sandra M.; Pereira, Cláudia F.Neurovascular dysfunction arising from endothelial cell damage is an early pathogenic event that contributes to the neurodegenerative process occurring in Alzheimer's disease (AD). Since the mechanisms underlying endothelial dysfunction are not fully elucidated, this study was aimed to explore the hypothesis that brain endothelial cell death is induced upon the sustained activation of the endoplasmic reticulum ...
Neurotoxicity of heroin-cocaine combinations in rat cortical neurons
Cunha-Oliveira, Teresa; Rego, A Cristina; Garrido, Jorge; Borges, Fernanda; Macedo, Tice; Oliveira, Catarina RCocaine and heroin are frequently co-abused by humans, in a combination known as speedball. Recently, chemical interactions between heroin (Her) or its metabolite morphine (Mor) and cocaine (Coc) were described, resulting in the formation of strong adducts. In this work, we evaluated whether combinations of Coc and Her affect the neurotoxicity of these drugs, using rat cortical neurons incubated with Coc, Her, ...
Drugs of abuse induce apoptotic features in PC12 cells.
Oliveira, M Teresa; Rego, A Cristina; Macedo, Tice R; Oliveira, Catarina RDrugs of abuse induce the release of dopamine in the central nervous system, particularly in the mesolimbic-mesocortical pathway. As dopamine may act as a neurotoxin, in this study, we analyzed the effects of the drugs of abuse, cocaine, heroin, and amphetamine, on the neurodegeneration of PC12 cells, a dopaminergic cell line, by evaluating the activity of caspase-3 and mitochondrial cytochrome c release. All t...
Toxic Effects of Opioid and Stimulant Drugs on Undifferentiated PC12 Cells
Oliveira, M Teresa; Rego, A Cristina; Morgadinho, M Teresa; Macedo, Tice R; Oliveira, Catarina RCell death and reactive oxygen species production have been suggested to be involved in neurodegeneration induced by the drugs of abuse. In this study we analyze the toxicity of the following drugs of abuse: heroin, morphine, d-amphetamine, and cocaine in undifferentiated PC12 cells, used as dopaminergic neuronal models. Our data show that opioid drugs (heroin and morphine) are more toxic than stimulant drugs (...
Expression of NR1/NR2B N-Methyl-d-Aspartate Receptors Enhances Heroin Toxicity ...
Domingues, António; Cunha-Oliveira, Teresa; Laço, Mário LN; Macedo, Tice; Oliveira, Catarina R; Rego, A CristinaRepeated use of drugs of abuse, namely opiates, has been shown to affect glutamate-releasing neurons. Moreover, blockade of N-methyl-D-aspartate (NMDA) receptors (NMDAR) prevents cell death by apoptosis induced by morphine, a heroin metabolite. Thus, in this article we investigated the involvement of different NMDAR subunits in heroin cytotoxicity. Human embryonic kidney (HEK293)cells, which do not express nati...
Efeito crónico da heroína e do peróxido de hidrogénio em células PC12
Cunha-Oliveira, Teresa; Rego, A Cristina; Morgadinho, M Teresa; Macedo, Tice R; Oliveira, Catarina RO consumo repetido de drogas, nomeadamente opióides, conduz ao desenvolvimento de dependência. Entre os mecanismos envolvidos neste processo, comuns à maioria das drogas de abuso, destaca-se a activação da neurotransmissão dopaminérgica em zonas específicas do cérebro. O metabolismo oxidativo da dopamina confere-lhe um potencial neurotóxico devido à formação de espécies reactivas de oxigénio, nomeadamente peróx...
Glutathione redox cycle dysregulation in Huntington’s disease knock-in striatal...
Ribeiro, Márcio; Rosenstock, Tatiana; Cunha-Oliveira, Teresa; Ferreira, Ildete; Oliveira, Catarina R.; Rego, Ana CristinaHuntington’s disease (HD) is a CAG repeat disorder affecting the HD gene, which encodes for huntingtin (Htt) and is characterized by prominent cell death in the striatum. Oxidative stress was previously implicated in HD neurodegeneration, but the role of the major endogenous antioxidant system, the glutathione redox cycle, has been less studied following expression of full-length mutant Htt (FL-mHtt). Thus, in ...
N-acyldopamines control striatal input terminals via novel ligand-gated cation ...
Ferreira, Samira G.; Lomaglio, Tonia; Avelino, Antonio; Cruz, Francisco; Oliveira, Catarina R.; Cunha, Rodrigo A.; Köfalvi, Attilahttp://www.sciencedirect.com/science/article/B6T0C-4V3HHM3-1/2/22d594101b6927eca47e1b39b53ffcee
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