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Molecular detection of EGFRvIII-positive cells in the peripheral blood of breas...
Silva, Henriqueta A. C.; Abraúl, Elsa; Raimundo, Dulce; Dias, Margarida F.; Marques, Carlos; Guerra, Carlos; Oliveira, Carlos F. deThe aim of this study is to evaluate epidermal growth factor receptor variant III, EGFRvIII, a cancer specific mutant, as a possible marker for the diagnosis of breast cancer occult systemic disease. EGFRvIII mRNA was identified by an RT-nested PCR with a high sensitivity. In 102 women studied, the mutant was detected in the peripheral blood of 30% of 33 low risk, early stage patients, in 56% of 18 patients sel...
Drawbacks of ovarian ablation with goserelin in women with breast cancer.
Franco, Sofia; Lupa, Paula; Guerra, Carlos; Pereira, Luís; Oliveira, Carlos F deIn the last few years, ovarian ablation with GnRH agonists has been used as first-line adjuvant therapy in pre and perimenopausal breast cancer. These drugs suppress ovarian function in the hypothalamic-pituitary axis and they have adverse effects in other end-organs. A retrospective study was conducted on 35 premenopausal women, with breast cancer, and treated with goserelin, in order to investigate the effect...
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