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Molecular detection of EGFRvIII-positive cells in the peripheral blood of breas...
Silva, Henriqueta A. C.; Abraúl, Elsa; Raimundo, Dulce; Dias, Margarida F.; Marques, Carlos; Guerra, Carlos; Oliveira, Carlos F. deThe aim of this study is to evaluate epidermal growth factor receptor variant III, EGFRvIII, a cancer specific mutant, as a possible marker for the diagnosis of breast cancer occult systemic disease. EGFRvIII mRNA was identified by an RT-nested PCR with a high sensitivity. In 102 women studied, the mutant was detected in the peripheral blood of 30% of 33 low risk, early stage patients, in 56% of 18 patients sel...
Breast pathology: evaluation of the Portuguese scientific activity based on bib...
Donato, Helena M; De Oliveira, Carlos FThe bibliometric analysis of the Portuguese scientific production in the field of breast pathology since 1995 to date (July 2005) provides an overview on the developed scientific activity on this subject and allows the characterisation of some relevant features as well as its evolution along the studied period.Documents collected, reflecting the national scientific production in the field of breast pathology be...
Drawbacks of ovarian ablation with goserelin in women with breast cancer.
Franco, Sofia; Lupa, Paula; Guerra, Carlos; Pereira, Luís; Oliveira, Carlos F deIn the last few years, ovarian ablation with GnRH agonists has been used as first-line adjuvant therapy in pre and perimenopausal breast cancer. These drugs suppress ovarian function in the hypothalamic-pituitary axis and they have adverse effects in other end-organs. A retrospective study was conducted on 35 premenopausal women, with breast cancer, and treated with goserelin, in order to investigate the effect...
Atypical glandular cells of undetermined significance (agus) which entity?.
Rebelo, M Teresa; Dias, Margarida F; Amaral, Natália; Dinis, Madalena; Oliveira, Carlos F; Oliveira, Henrique MOBJECTIVE : The aim of this study was to determine the incidence and evolution of the atypical glandular cells of undetermined significance (AGUS) without associated lesions identified on cervical Pap smear. MATERIAL AND METHODS : Retrospective study concerning 33.923 cervicovaginal smears performed in the Cytopathology Department of the Coimbra University Hospital (H.U.C.) between January 1995 an December 1997...
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