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Mitochondrial Dysfunction: The Road to Alpha-Synuclein Oligomerization in PD
Esteves, A. R.; Arduíno, D. M.; Silva, D. F. F.; Oliveira, C. R.; Cardoso, S. M.While the etiology of Parkinson's disease remains largely elusive, there is accumulating evidence suggesting that mitochondrial dysfunction occurs prior to the onset of symptoms in Parkinson's disease. Mitochondria are remarkably primed to play a vital role in neuronal cell survival since they are key regulators of energy metabolism (as ATP producers), of intracellular calcium homeostasis, of NAD+/NADH ratio, a...
LaTEX: uma ferramenta para edição de textos técnico-científicos de alta qualidade.
OLIVEIRA, C. R. de; FERREIRA, E. J.2007
Desenvolvimento de catalisadores magnéticos para despoluição de água contaminad...
OLIVEIRA, C. R.; MOURÃO, H.A. de J. L.2007
Sistema de micromanipulação para montagem de amostras em microscopia.
OLIVEIRA, C. R. de; CAMARGO, E. R. de; BISCEGLI, C. I.; NOVAES, A. P. de.2007
Anandamide and NADA bi-directionally modulate presynaptic Ca<sup>2+</sup> level...
Köfalvi, A.; Pereira, M. F.; Rebola, N.; Rodrigues, R. J.; Oliveira, C. R.; Cunha, R. A.Inhibitory CB1 cannabinoid receptors and excitatory TRPV1 vanilloid receptors are abundant in the hippocampus. We tested if two known hybrid endocannabinoid/endovanilloid substances, N-arachidonoyl-dopamine (NADA) and anandamide (AEA), presynapticaly increased or decreased intracellular calcium level ([Ca2+]i) and GABA and glutamate release in the hippocampus. Resting and K+-evoked levels of [Ca2+]i and the rel...
Evaluation of laser-glazed plasma-sprayed thermal barriercoatings under high te...
Batista, C.; Portinha, Aníbal; Ribeiro, R. M.; Teixeira, Vasco M. P.; Oliveira, C. R.Thermal Barrier Coating (TBC) systems are frequently used in gas turbine engines to provide thermal insulation to the hot-section metallic components and also to protect them from oxidation, hot corrosion and erosion. Surface sealing treatments, namely laser-glazing, have been showing a high potential for extending in-service lifetimes of these systems by improving chemical and thermo-mechanical resistance. In ...
Morphological and microstructural characterization of laser-glazedplasma-spraye...
Ribeiro, R. M.; Teixeira, Vasco M. P.; Costa, M. F.; Oliveira, C. R.; Batista, C.; Portinha, AníbalLaser glazing has been revealing a high potential for the improvement of plasma-sprayed (PS) thermal barrier coatings (TBCs) by reducing surface roughness, eliminating open porosity on the surface and generating a controlled segmented crack network, although the relationship of the processing parameters with the resultant properties has not yet been completely established. In this investigation, TBCs consisting...
Effect of chronic exposure to aluminium on isoform expression and activity of r...
Silva, V. S.; Duarte, A. I.; Rego, A. C.; Oliveira, C. R.; Goncalves, P. P.The ability of aluminum to inhibit the (Na+/K+)ATPase activity has been observed by several investigators. The (Na+/K+)ATPase is characterized by a complex molecular heterogeneity that results from the expression and differential association of multiple isoforms of both catalytic (alpha) and regulatory (beta) subunits. For instance, three main alpha (alpha(1), alpha(2) and alpha(3)) and three beta (beta(1), bet...
Surface laser-glazing of plasma-sprayed thermal barrier coatings
Batista, C.; Portinha, Aníbal; Ribeiro, R. M.; Teixeira, Vasco M. P.; Costa, M. F.; Oliveira, C. R.Atmospheric plasma-sprayed (APS) ZrO2–8%WtY2O3 thermal barrier coatings (TBCs) were subjected to a CO2 continuous wave laser-glazing process in order to generate an external dense layer produced by different processing parameters. For that purpose, different beam scanning speeds and track overlapping were chosen. Surface roughness has been reduced significantly after laser-glazing. Despite the surface crack net...
IgA response in serum and gut secretion in sensitized mice fed with the dust mi...
Maciel,M.; Fusaro,A.E.; Oliveira,C.R.; Futata,E.A.; Duarte,A.J.S.; Sato,M.N.Induced oral tolerance to mucosal-exposed antigens in immunized animals is of particular interest for the development of immunotherapeutic approaches to human allergic diseases. This is a unique feature of mucosal surfaces which represent the main contact interface with the external environment. However, the influence of oral tolerance on specific and natural polyreactive IgA antibodies, the major defense mecha...
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