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Fluorescence studies of potential antitumoral 6-heteroarylthieno[3,2-b]pyridine...

Carvalho, M. Solange D.; Castanheira, Elisabete M. S.; Oliveira, Andreia D. S.; Calhelha, Ricardo C.; Queiroz, Maria João R. P.

Fluorescence properties of new potential antitumoral 6-heteroarylthieno[3,2-b]pyridines, recently synthesized, were studied in solution and in nanoliposomes of different compositions. The results indicate that these compounds can be transported in the hydrophobic region of the lipid bilayer. The liposomal formulation Egg-PC:Ch:DPPG (7:3:1) is the one with smaller size and lowest polydispersity.


New potential antitumoral di(hetero)arylether derivatives in the thieno[3,2-b]p...

Queiroz, Maria João R. P.; Dias, Sofia; Peixoto, Daniela; Rodrigues, Ana Rita O.; Oliveira, Andreia D. S.; Coutinho, Paulo J. G.; Silva, Luís A. Vale

New fluorescent methoxylated di(hetero)arylethers in the thieno[3,2-b]pyridine series were prepared by a copper-catalyzed Ullmann-type C-O coupling of the methyl 3-amino-6-bromothieno[3,2-b]pyridine-2-carboxylate with ortho, meta and para-methoxyphenols, using N,N-dimethylglycine as the ligand and Cs2CO3 as the base. The compounds obtained were tested for their inhibitory growth activity in three human tumor c...


Fluorescence studies of new potential antitumoral di(hetero)arylethers derivati...

Queiroz, Maria João R. P.; Castanheira, Elisabete M. S.; Oliveira, Andreia D. S.; Dias, Sofia; Coutinho, Paulo J. G.

Contribution (Poster)


Interaction of benzothienoquinolines with DNA and lipid membranes monitored by ...

Castanheira, Elisabete M. S.; Rodrigues, Ana Rita O.; Oliveira, Andreia D. S.; Calhelha, Ricardo C.; Queiroz, Maria João R. P.

RICI4 - Book of Abstracts


Encapsulation of a new antitumoral fluorescent 6-(benzo[d]thiazo-2-ylamino)thie...

Oliveira, Andreia D. S.; Castanheira, Elisabete M. S.; Calhelha, Ricardo C.; Silva, Luís A. Vale; Pinto, Eugénia; Queiroz, Maria João R. P.

Publicado no suplemento da Revista Portuguesa de Farmácia, Vol. 50, nº 4


Fluorescence studies of benzothienoquinolines in lipid membranes

Oliveira, Andreia D. S.; Castanheira, Elisabete M. S.; Coutinho, Paulo J. G.; Calhelha, Ricardo C.; Queiroz, Maria João R. P.


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Fundação para a Ciência e a Tecnologia Universidade do Minho   Governo Português Ministério da Educação e Ciência Programa Operacional da Sociedade do Conhecimento União Europeia