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Margem Oeste Portuguesa

Mundos dentro de um mundo: representações interculturais na Polónia sob a influ...

Europa, 1939 A Alemanha, sob a influência do partido Alemão Nazi, deu início a um confronto que mudou a face do mundo. Inicialmente os seus países vizinhos Europeus, depois alguns mais distantes e até o continente Africano sentiram o seu poder e tremeram de medo. Medo, um sentimento tão poderoso que em pequenas quantidades, pode aguçar os sentidos mas que, em quantidades grandes, pode gerar pânico, suprimir o i...

Animal welfare in studies on murine tuberculosis : assessing progress over a 12...

There is growing concern over the welfare of animals used in research, in particular when these animals develop pathology. The present study aims to identify the main sources of animal distress and to assess the possible implementation of refinement measures in experimental infection research, using mouse models of tuberculosis (TB) as a case study. This choice is based on the historical relevance of mouse stud...

How “humane” is your endpoint? — Refining the science-driven approach for termi...

Public concern on issues such as animal welfare or the scientific validity and clinical value of animal research is growing, resulting in increasing regulatory demands for animal research. Abiding to the most stringent animal welfare standards, while having scientific objectives as the main priority, is often challenging. To do so, endpoints of studies involving severe, progressive diseases need to be establish...

Lipocalin 2 is present in the EAE brain and is modulated by natalizumab

The authors acknowledge the BiogenIdec,for providing Natalizumab (BiogenIdec, Boston,MA,USA).We are thankful to theCOST(EuropeanCooperationinScienceandTechnology) ActionNEURINFNETBM0603.WealsothankDr.NadineSantos for criticallyreviewingthismanuscript. ; Multiple sclerosis (MS) is a demyelinating disease that causes major neurological disability in young adults. A definitive diagnosis at the time of the first e...

Seismic Analysis and Strengthening of Pico Island Churches

The proposed study addresses the development of an integrated strategy for modelling, experimental calibration, numerical analysis and seismic strengthening carried out in two churches of the Pico Island, Azores, namely the Bandeiras and the Madalena churches. Following an initial description of the observed damages resulting from the 1998 earthquake, the modelling option for the churches’ structures is o...

Seismic Analysis of a Building Block. Bulletin of Earthquake Engineering

This paper reports on the study of the seismic response of an urban building block located in Faial, a town of the Horta Island of the Azores, Portugal. The work fits within the framework of studying strengthening schemes suitable for the reconstruction process of a town damaged by an earthquake action and includes numerical modelling of all the building blocks with calibration of material and structural parame...

A laparoscopic surgery training interface

Laparoscopy is a surgical procedure on which operations in the abdomen are performed through small incisions using several specialized instruments. The laparoscopic surgery success greatly depends on surgeon skills and training. To achieve these technical high-standards, different apprenticeship methods have been developed, many based on in vivo training, an approach that involves high costs and complex setup p...

Transcriptome signature of the adult mouse choroid plexus

Background: Although the gene expression profile of several tissues in humans and in rodent animal models has been explored, analysis of the complete choroid plexus (CP) transcriptome is still lacking. A better characterization of the CP transcriptome can provide key insights into its functions as one of the barriers that separate the brain from the periphery and in the production of cerebrospinal fluid. Method...

Role playing games and emotions in dispute resolution environments

Electronic contracting, mostly through software agents, led to an impressive growth in electronic transactions, but also in the number of disputes arising out of these transactions. Paper-based courts are however unable to efficiently deal with this increase in disputes. On the other hand, current Online Dispute Resolution methodologies are impersonal and cold, leaving aside important information such as the di...